(S)-N,N-二甲基哌啶-3-胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)—N,N-dimethylpiperidin-3-amine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (d, J=11.12 Hz, 1 H) 1.78 (m, J=16.20 Hz, 2 H) 2.12 (d, J=10.86 Hz, 1 H) 2.33 (d, J=2.27 Hz, 3 H) 2.67-2.94 (m, 6 H) 3.13-4.79 (m, 5 H) 7.48-7.70 (m, 1 H) 7.70-7.80 (m, 1 H) 7.98-8.34 (m, 2 H) 8.57 (m, J=1.50 Hz, 2 H) 9.44-10.31 (m, 1 H). ESI-MS m/z [M+H]+ 449.3.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)—N,N-dimethylpiperidin-3-amine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (d, J=11.12 Hz, 1 H) 1.78 (m, J=16.20 Hz, 2 H) 2.12 (d, J=10.86 Hz, 1 H) 2.33 (d, J=2.27 Hz, 3 H) 2.67-2.94 (m, 6 H) 3.13-4.79 (m, 5 H) 7.48-7.70 (m, 1 H) 7.70-7.80 (m, 1 H) 7.98-8.34 (m, 2 H) 8.57 (m, J=1.50 Hz, 2 H) 9.44-10.31 (m, 1 H). ESI-MS m/z [M+H]+ 449.3.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)—N,N-dimethylpiperidin-3-amine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (d, J=11.12 Hz, 1H) 1.78 (m, J=16.20 Hz, 2H) 2.12 (d, J=10.86 Hz, 1H) 2.33 (d, J=2.27 Hz, 3H) 2.67-2.94 (m, 6H) 3.13-4.79 (m, 5H) 7.48-7.70 (m, 1H) 7.70-7.80 (m, 1H) 7.98-8.34 (m, 2H) 8.57 (m, J=1.50 Hz, 2H) 9.44-10.31 (m, 1H). ESI-MS m/z [M+H]+ 449.3.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)—N,N-dimethylpiperidin-3-amine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (d, J=11.12 Hz, 1 H) 1.78 (m, J=16.20 Hz, 2 H) 2.12 (d, J=10.86 Hz, 1 H) 2.33 (d, J=2.27 Hz, 3 H) 2.67-2.94 (m, 6 H) 3.13-4.79 (m, 5 H) 7.48-7.70 (m, 1 H) 7.70-7.80 (m, 1 H) 7.98-8.34 (m, 2 H) 8.57 (m, J=1.50 Hz, 2 H) 9.44-10.31 (m, 1 H). ESI-MS m/z [M+H]+ 449.3.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and (S)—N,N-dimethylpiperidin-3-amine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.54 (d, J=11.12 Hz, 1H) 1.78 (m, J=16.20 Hz, 2H) 2.12 (d, J=10.86 Hz, 1H) 2.33 (d, J=2.27 Hz, 3H) 2.67-2.94 (m, 6H) 3.13-4.79 (m, 5H) 7.48-7.70 (m, 1H) 7.70-7.80 (m, 1H) 7.98-8.34 (m, 2H) 8.57 (m, J=1.50 Hz, 2H) 9.44-10.31 (m, 1H). ESI-MS m/z [M+H]+ 449.3.