2,3-二氟-6-甲氧基氯苄

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 2,3-difluoro-6-methoxybenzyl chloride (7.65 g), 4-chloro-2-methoxyphenol (6.34 g), potassium carbonate (8.29 g) and sodium iodide (1.2 g) in N,N-dimethylformamide (20 mL) was stirred at 80° C. for 2 hours. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The extract was washed with 1 mol/L aqueous sodium hydroxide solution, water and brine successively, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residual solids were suspended in a mixed solvent (n-hexane/diethyl ether=5/1), and collected by filtration. The collected solids were washed with the same solvent, and dried under reduced pressure to give the title compound (8.6 g). the resulting mixture was extracted with diethyl ether The extract was washed with 1 mol/L aqueous sodium hydroxide solution, water and brine successively dried over anhydrous magnesium sulfate the solvent was removed under reduced pressure collected by filtration The collected solids were washed with the same solvent dried under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 2,3-difluoro-6-methoxybenzyl alcohol (6.97 g) in toluene (100 mL) was added thionyl chloride (4.4 mL) in a dropwise manner at room temperature, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was poured into water, and the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine twice, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the title compound (7.65 g). the resulting mixture was extracted with ethyl acetate The extract was washed with water and brine twice dried over anhydrous sodium sulfate The solvent was removed under reduced pressure