十四烷酸（肉豆蔻酸)异丙酯

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The obtained olopatadine hydrochloride was mixed with about 2 mL of ethyl acetate. The mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order to dissolve or disperse olopatadine hydrochloride, and fully mixed with isopropyl myristate. Acrylic pressure sensitive adhesive 3.7125 g (PE-300; acrylate copolymer; solid content of 40% by weight (ethyl acetate/toluene mixed solvent): 1.485 g; Nippon Carbide Industries Co., Ltd.) and crosslinking agent 0.015 g (CK401; metal chelate; solid content of about 10% by weight (toluene solvent): 0.0015 g; Nippon Carbide Industries Co., Ltd.) were sequentially added to the mixture. The mixture was fully mixed and degassed. The mixture was spread over release liner using metering knife or baker applicator, and stood until the organic solvent was completely evaporated. Subsequently, support was laid over the release liner and compressed using roller, and subjected to crosslinking in temperature controlled bath for 8 to 12 hours at about 40° C. to give adhesive preparation comprising olopatadine hydrochloride. The mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order to dissolve were sequentially added to the mixture The mixture was fully mixed degassed was completely evaporated for 8 to 12 hours at about 40° C. to give adhesive preparation

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The foregoing formula may require a solubilizing agent, e.g., the methyl ester of dihydroabietic acid (commercial name: HERCOLYN D® , benzyl benzoate, isopropyl myristate and/or C12 -C14 isoparaffin hydrocarbons.

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The premix test was carried out as follows. First, into a screw tube, isopropyl myristate (21 g) was added and heated at 80° C. Into the screw tube, a 10 wt % dispersion liquid of G4 in propylene glycol (6.6 g) heated at 80° C. was added and made into a homogeneous solution, and then water (9 g) heated at 70° C. was added. The mixture was stirred with a homogenizer for 10 minutes, thus yielding a water/isopropyl myristate dispersion gel. was added was added

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The foregoing formula may require a solubilizing agent, e.g., the methyl ester of dihydroabietic acid (commercial name: HERCOLYN D®, benzyl benzoate, isopropyl myristate and/or C12 -C14 isoparaffin hydrocarbons.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The foregoing formula may require a solubilizing agent, e.g., the methyl ester of dihydroabietic acid (commercial name: HERCOLYN D®, benzyl benzoate, isopropyl myristate and/or C12 -C14 isoparaffin hydrocarbons.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The foregoing formula may require a solubilizing agent, e.g., the methyl ester of dihydroabietic acid (commerical name: HERCOLYN D®), benzyl benzoate, isopropyl myristate and/or C12 -C14 isoparaffin hydrocarbons.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The obtained olopatadine hydrochloride was mixed with about 2 mL of ethyl acetate. The mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order to dissolve or disperse olopatadine hydrochloride, and fully mixed with isopropyl myristate. Acrylic pressure sensitive adhesive 3.7125 g (PE-300; acrylate copolymer; solid content of 40% by weight (ethyl acetate/toluene mixed solvent): 1.485 g; Nippon Carbide Industries Co., Ltd.) and crosslinking agent 0.015 g (CK401; metal chelate; solid content of about 10% by weight (toluene solvent): 0.0015 g; Nippon Carbide Industries Co., Ltd.) were sequentially added to the mixture. The mixture was fully mixed and degassed. The mixture was spread over release liner using metering knife or baker applicator, and stood until the organic solvent was completely evaporated. Subsequently, support was laid over the release liner and compressed using roller, and subjected to crosslinking in temperature controlled bath for 8 to 12 hours at about 40° C. to give adhesive preparation comprising olopatadine hydrochloride. The mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order to dissolve were sequentially added to the mixture The mixture was fully mixed degassed was completely evaporated for 8 to 12 hours at about 40° C. to give adhesive preparation

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The obtained olopatadine hydrochloride was mixed with about 2 mL of ethyl acetate. The mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order to dissolve or disperse olopatadine hydrochloride, and fully mixed with isopropyl myristate. Acrylic pressure sensitive adhesive 3.7125 g (PE-300; acrylate copolymer; solid content of 40% by weight (ethyl acetate/toluene mixed solvent): 1.485 g; Nippon Carbide Industries Co., Ltd.) and crosslinking agent 0.015 g (CK401; metal chelate; solid content of about 10% by weight (toluene solvent): 0.0015 g; Nippon Carbide Industries Co., Ltd.) were sequentially added to the mixture. The mixture was fully mixed and degassed. The mixture was spread over release liner using metering knife or baker applicator, and stood until the organic solvent was completely evaporated. Subsequently, support was laid over the release liner and compressed using roller, and subjected to crosslinking in temperature controlled bath for 8 to 12 hours at about 40° C. to give adhesive preparation comprising olopatadine hydrochloride. The mixture was subjected to ultrasonication in disposable cup for about 30 seconds in order to dissolve were sequentially added to the mixture The mixture was fully mixed degassed was completely evaporated for 8 to 12 hours at about 40° C. to give adhesive preparation

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The foregoing formula may require a solubilizing agent, e.g., the methyl ester of dihydroabietic acid (commercial name: HERCOLYN D® , benzyl benzoate, isopropyl myristate and/or C12 -C14 isoparaffin hydrocarbons.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The foregoing formula may require a solubilizing agent, e.g., the methyl ester of dihydroabietic acid (commercial name: HERCOLYN D® , benzyl benzoate, isopropyl myristate and/or C12 -C14 isoparaffin hydrocarbons.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The foregoing formula may require a solubilizing agent, e.g., the methyl ester of dihydroabietic acid (commerical name:HERCOLYN D®), benzyl benzoate, isopropyl myristate and/or C12 -C14 isoparaffin hydrocarbons.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Linoleic acid (5 parts) and isopropyl myristate (2 parts) are added to cetyl alcohol (70 parts) molten at 50° C. A solution obtained by successively dissolving menthol (0.25 part), eucalyptol (0.5 part) and camphor (0.25 part) in cineol (3 parts), at a temperature of the order of 20° C., is added to the resulting solution. This gives a phase φ1. molten at 50° C