HYDROXYAMBRAN

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 15 g of 2-cyclododecylpropan-l-ol were stirred with 4 g of sodium hydride in 150 ml of tetrahydrofuran for two hours at the boiling temperature excluding air. 6 g of diethyl sulfate were then added dropwise, and the mixture was refluxed for a further two hours. The cooled reaction mixture was poured onto ice and extracted by stirring with 20 ml of 10% strength NaOH and 50 ml of tert.-butyl methyl ether. The aqueous layer was again extracted by shaking with tert.-butyl methyl ether, and the combined organic layers were again extracted by shaking with 10% strength NaOH and distilled. After removal of the solvents, 9.5 g of 2-cyclododecylpropyl ethyl ether were obtained at 92-95° C. and 0.2 mbar. the mixture was refluxed for a further two hours The cooled reaction mixture was poured onto ice extracted The aqueous layer was again extracted by shaking with tert.-butyl methyl ether the combined organic layers were again extracted by shaking with 10% strength NaOH distilled After removal of the solvents

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 45 g of the mixture of isomers of 2-cyclododecenylpropan-l-ol from Example 1 were heated for 7 hours at 200° with 2 g of Raney nickel and 10 ml of ethanol in a shaken autoclave with 200 bar of hydrogen After removal of catalyst and solvent, the reaction mixture was distilled. At 105-110° C. and 0.7 mbar, 35 g of 2-cyclododecylpropan-l-ol were obtained. After removal of catalyst and solvent the reaction mixture was distilled