暂无可渲染的结构数据
CCCC(CC(=O)OCC)O[Si](C)(C)C(C)(C)C中间体产品
ethyl 3-[tert-butyl(dimethyl)silyl]oxyhexanoate
结构、标识符和计算性质已按 CAS 与数据库记录完成匹配。
| 中文名称 | ethyl 3-[tert-butyl(dimethyl)silyl]oxyhexanoate |
|---|---|
| English name | ethyl 3-[tert-butyl(dimethyl)silyl]oxyhexanoate |
| IUPAC 名称 | — |
| CAS号 | 123731-53-3 |
| 数据库编号 | 14264095 |
| 分子式 | — |
| 分子量 | — |
产品信息
ethyl 3-[tert-butyl(dimethyl)silyl]oxyhexanoate（CAS 123731-53-3）的产品身份、结构标识及相关反应资料，供化学中间体检索、研发和采购评估使用。
可能的应用方向
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数据库编号 14264095
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合成路线数据
10 条反应 · 10 篇文献
反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Ethyl 6-((tert-butyldimethylsilyl)oxy)hexanoate 8 (3.08 g) was prepared in 90% yield using ethyl 6-hydroxyhexanoate 7 according to the procedures described for compound 2 in above (see Schemes 1-3).
来源 ID: ord-33b678d928f24c988ed33f52f0f4cbaa反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Ethyl 6-((tert-butyldimethylsilyl)oxy)hexanoate 8 (3.08 g) was prepared in 90% yield using ethyl 6-hydroxyhexanoate 7 according to the procedures described for compound 2 in above (see Schemes 1-3).
来源 ID: ord-33b678d928f24c988ed33f52f0f4cbaa反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Ethyl 2-((tert-butyldimethylsilyl)oxy)hexanoate 5 (2.54 g) was prepared in 74% yield using ethyl 2-hydroxyhexanoate 4 according to the procedures described for compound 2 in above (See Schemes 1 and 2).
来源 ID: ord-00d067e7cf0a4607a2a98b5a0ecc09f8反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: n-Butyllithium (6.8 mL of a 1.6M solution in THF, 10.94 mmol) was added to a solution of dimethyl methylphosphonate (1.2 mL, 10.94 mmol) in THF (22 mL) at −78° C. After 0.5 h a solution of the ester 2 (2.0 g, 7.29 mmol) in THF (4 mL) was added. The reaction solution was allowed to warm to room temperature overnight on its own accord. After 16 h the reaction was quenched with saturated aqueous ammonium chloride and extracted with EtOAc. The organic portion was washed with brine, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 2:1 hex/EtOAc followed by 1:1 hex/EtOAc) afforded 0.93 g (36%) of phosphonate 3 (see Scheme 1). After 16 h the reaction was quenched with saturated aqueous ammonium chloride extracted with EtOAc The organic portion was washed with brine dried (MgSO4) filtered concentrated in vacuo The residue was purified by flash column chromatography (silica gel, 2:1 hex/EtOAc followed by 1:1 hex/EtOAc)
来源 ID: ord-9131a0a39fe546ef82b4f40a0381779a反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of ethyl 3-hydroxyhexanoate 1 (2.0 g, 12.5 mmol), imidazole (1.09 g, 18.7 mmol), and tert-butyldimethylsilyl chloride (2.26 g, 15.0 mmol) in DMF (25 mL) was stirred at 23° C. After 16 h the reaction was diluted with Et2O and then washed with 1N HCl, saturated aqueous NaHCO3 and brine. The organic portion was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 100% hex followed by 19:1 hex/EtOAc) afforded 2.8 g (82%) of silyl ether 2 (see Scheme 1). washed with 1N HCl, saturated aqueous NaHCO3 and brine The organic portion was dried (MgSO4) filtered concentrated in vacuo The residue was purified by flash column chromatography (silica gel, 100% hex followed by 19:1 hex/EtOAc)
来源 ID: ord-7f65529dc22c4fb1bd9fece3faf73783反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of ethyl 3-hydroxyhexanoate 1 (2.0 g, 12.5 mmol), imidazole (1.09 g, 18.7 mmol), and tert-butyldimethylsilyl chloride (2.26 g, 15.0 mmol) in DMF (25 mL) was stirred at 23° C. After 16 h the reaction was diluted with Et2O and then washed with 1N HCl, saturated aqueous NaHCO3 and brine. The organic portion was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 100% hex followed by 19:1 hex/EtOAc) afforded 2.8 g (82%) of silyl ether 2 (see Scheme 1). washed with 1N HCl, saturated aqueous NaHCO3 and brine The organic portion was dried (MgSO4) filtered concentrated in vacuo The residue was purified by flash column chromatography (silica gel, 100% hex followed by 19:1 hex/EtOAc)
来源 ID: ord-7f65529dc22c4fb1bd9fece3faf73783反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Ethyl 6-((tert-butyldimethylsilyl)oxy)hexanoate 8 (3.08 g) was prepared in 90% yield using ethyl 6-hydroxyhexanoate 7 according to the procedures described for compound 2 in above (see Schemes 1-3).
来源 ID: ord-33b678d928f24c988ed33f52f0f4cbaa反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Ethyl 2-((tert-butyldimethylsilyl)oxy)hexanoate 5 (2.54 g) was prepared in 74% yield using ethyl 2-hydroxyhexanoate 4 according to the procedures described for compound 2 in above (See Schemes 1 and 2).
来源 ID: ord-00d067e7cf0a4607a2a98b5a0ecc09f8反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: n-Butyllithium (6.8 mL of a 1.6M solution in THF, 10.94 mmol) was added to a solution of dimethyl methylphosphonate (1.2 mL, 10.94 mmol) in THF (22 mL) at −78° C. After 0.5 h a solution of the ester 2 (2.0 g, 7.29 mmol) in THF (4 mL) was added. The reaction solution was allowed to warm to room temperature overnight on its own accord. After 16 h the reaction was quenched with saturated aqueous ammonium chloride and extracted with EtOAc. The organic portion was washed with brine, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 2:1 hex/EtOAc followed by 1:1 hex/EtOAc) afforded 0.93 g (36%) of phosphonate 3 (see Scheme 1). After 16 h the reaction was quenched with saturated aqueous ammonium chloride extracted with EtOAc The organic portion was washed with brine dried (MgSO4) filtered concentrated in vacuo The residue was purified by flash column chromatography (silica gel, 2:1 hex/EtOAc followed by 1:1 hex/EtOAc)
来源 ID: ord-9131a0a39fe546ef82b4f40a0381779a反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of ethyl 3-hydroxyhexanoate 1 (2.0 g, 12.5 mmol), imidazole (1.09 g, 18.7 mmol), and tert-butyldimethylsilyl chloride (2.26 g, 15.0 mmol) in DMF (25 mL) was stirred at 23° C. After 16 h the reaction was diluted with Et2O and then washed with 1N HCl, saturated aqueous NaHCO3 and brine. The organic portion was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 100% hex followed by 19:1 hex/EtOAc) afforded 2.8 g (82%) of silyl ether 2 (see Scheme 1). washed with 1N HCl, saturated aqueous NaHCO3 and brine The organic portion was dried (MgSO4) filtered concentrated in vacuo The residue was purified by flash column chromatography (silica gel, 100% hex followed by 19:1 hex/EtOAc)
来源 ID: ord-7f65529dc22c4fb1bd9fece3faf73783PubChem References
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