3-(2-氯苯基)哌嗪-2-酮

反应条件: temp:55.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 2-(-5-(4-cyanobenzyl)-imidazolyl)ethyl methanesulfonate (24 mg, 0.079 mmol) in DMF (0.2 ml) was added to 3-(chlorophenyl)piperazin-2-one (17.7 mg, 0.084 mmol), sodium iodide (50 mg, 0.336 mmol) and Hunigs base (0,0146 ml, 0.084 mmol). The mixture was stirred at 55° C. for 12 hours, and the solvent evaporated in vacuo. The residue was purified by preparative tic eluting with 10% saturated ammonia/acetonitrile to afford the title compound. 1H NMR δ CDCl3 (7.61 (2H, d, J=8.4 Hz), 7.56 (1H, s), 7.35-7.20 (7H, m), 7.16 (1H, d, J=8 Hz), 6.85 (1H, s), 4.03 (2H, s), 3.83 (2H, t, J=6.5 Hz),3.61 (2H, t, J=5.4 Hz), 3.27 (2H, s), 2.68 (2H, t, J=5.4 and 2.57 (2H, t, J=6.5 Hz) ppm. the solvent evaporated in vacuo The residue was purified by preparative tic eluting with 10% saturated ammonia/acetonitrile

反应条件: temp:55.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 2-(-5-(4-cyanobenzyl)-imidazolyl)ethyl methanesulfonate (24 mg, 0.079 mmol) in DMF (0.2 ml) was added to 3-(chlorophenyl)piperazin-2-one (17.7 mg, 0.084 mmol), sodium iodide (50 mg, 0.336 mmol) and Hunigs base (0,0146 ml, 0.084 mmol). The mixture was stirred at 55° C. for 12 hours, and the solvent evaporated in vacuo. The residue was purified by preparative tic eluting with 10% saturated ammonia/acetonitrile to afford the title compound. 1H NMR δ CDCl3 (7.61 (2H, d, J=8.4 Hz), 7.56 (1H, s), 7.35-7.20 (7H, m), 7.16 (1H, d, J=8 Hz), 6.85 (1H, s), 4.03 (2H, s), 3.83 (2H, t, J=6.5 Hz),3.61 (2H, t, J=5.4 Hz), 3.27 (2H, s), 2.68 (2H, t, J=5.4 and 2.57 (2H, t, J=6.5 Hz) ppm. the solvent evaporated in vacuo The residue was purified by preparative tic eluting with 10% saturated ammonia/acetonitrile

反应条件: temp:55.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 2-(-5-(4-cyanobenzyl)-imidazolyl)ethyl methanesulfonate (24 mg, 0.079 mmol) in DMF (0.2 ml) was added to 3-(chlorophenyl)piperazin-2-one (17.7 mg, 0.084 mmol), sodium iodide (50 mg, 0.336 mmol) and Hunigs base (0,0146 ml, 0.084 mmol). The mixture was stirred at 55° C. for 12 hours, and the solvent evaporated in vacuo. The residue was purified by preparative tic eluting with 10% saturated ammonia/acetonitrile to afford the title compound. 1H NMR δ CDCl3 (7.61 (2H, d, J=8.4 Hz), 7.56 (1H, s), 7.35-7.20 (7H, m), 7.16 (1H, d, J=8 Hz), 6.85 (1H, s), 4.03 (2H, s), 3.83 (2H, t, J=6.5 Hz),3.61 (2H, t, J=5.4 Hz), 3.27 (2H, s), 2.68 (2H, t, J=5.4 and 2.57 (2H, t, J=6.5 Hz) ppm. the solvent evaporated in vacuo The residue was purified by preparative tic eluting with 10% saturated ammonia/acetonitrile

反应条件: temp:55.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 2-(-5-(4-cyanobenzyl)-imidazolyl)ethyl methanesulfonate (24 mg, 0.079 mmol) in DMF (0.2 ml) was added to 3-(chlorophenyl)piperazin-2-one (17.7 mg, 0.084 mmol), sodium iodide (50 mg, 0.336 mmol) and Hunigs base (0,0146 ml, 0.084 mmol). The mixture was stirred at 55° C. for 12 hours, and the solvent evaporated in vacuo. The residue was purified by preparative tic eluting with 10% saturated ammonia/acetonitrile to afford the title compound. 1H NMR δ CDCl3 (7.61 (2H, d, J=8.4 Hz), 7.56 (1H, s), 7.35-7.20 (7H, m), 7.16 (1H, d, J=8 Hz), 6.85 (1H, s), 4.03 (2H, s), 3.83 (2H, t, J=6.5 Hz),3.61 (2H, t, J=5.4 Hz), 3.27 (2H, s), 2.68 (2H, t, J=5.4 and 2.57 (2H, t, J=6.5 Hz) ppm. the solvent evaporated in vacuo The residue was purified by preparative tic eluting with 10% saturated ammonia/acetonitrile