5-溴-2-羟基-3-丙-2-基苯甲醛

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 5-bromo-2-hydroxy-3-isopropylbenzaldehyde (25.88 g) was dissolved in N,N-dimethylformamide (100 mL), and potassium carbonate (27.64 g) and dimethylsulfuric acid (9.5 mL) were added to the solution under water cooling, and the mixture was stirred at room temperature for 2 hours. Water was added to the reaction solution, and then the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (26.76 g) as a brown oily substance. the reaction mixture was extracted with ethyl acetate The organic layer was washed with water and saturated brine dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2-hydroxy-3-isopropylbenzaldehyde (20.19 g) was dissolved in acetonitrile (160 mL), and N-bromosuccinimide (17.80 g) was added to the solution at 0° C., and then the mixture was stirred at room temperature for 4 hours. The solvent was distilled off under reduced pressure and water was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (25.88 g) as a yellow oily substance. The solvent was distilled off under reduced pressure and water was added the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 5-bromo-2-hydroxy-3-isopropylbenzaldehyde (25.88 g) was dissolved in N,N-dimethylformamide (100 mL), and potassium carbonate (27.64 g) and dimethylsulfuric acid (9.5 mL) were added to the solution under water cooling, and the mixture was stirred at room temperature for 2 hours. Water was added to the reaction solution, and then the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (26.76 g) as a brown oily substance. the reaction mixture was extracted with ethyl acetate The organic layer was washed with water and saturated brine dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 5-bromo-2-hydroxy-3-isopropylbenzaldehyde (25.88 g) was dissolved in N,N-dimethylformamide (100 mL), and potassium carbonate (27.64 g) and dimethylsulfuric acid (9.5 mL) were added to the solution under water cooling, and the mixture was stirred at room temperature for 2 hours. Water was added to the reaction solution, and then the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (26.76 g) as a brown oily substance. the reaction mixture was extracted with ethyl acetate The organic layer was washed with water and saturated brine dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2-hydroxy-3-isopropylbenzaldehyde (20.19 g) was dissolved in acetonitrile (160 mL), and N-bromosuccinimide (17.80 g) was added to the solution at 0° C., and then the mixture was stirred at room temperature for 4 hours. The solvent was distilled off under reduced pressure and water was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (25.88 g) as a yellow oily substance. The solvent was distilled off under reduced pressure and water was added the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 5-bromo-2-hydroxy-3-isopropylbenzaldehyde (25.88 g) was dissolved in N,N-dimethylformamide (100 mL), and potassium carbonate (27.64 g) and dimethylsulfuric acid (9.5 mL) were added to the solution under water cooling, and the mixture was stirred at room temperature for 2 hours. Water was added to the reaction solution, and then the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (26.76 g) as a brown oily substance. the reaction mixture was extracted with ethyl acetate The organic layer was washed with water and saturated brine dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2-hydroxy-3-isopropylbenzaldehyde (20.19 g) was dissolved in acetonitrile (160 mL), and N-bromosuccinimide (17.80 g) was added to the solution at 0° C., and then the mixture was stirred at room temperature for 4 hours. The solvent was distilled off under reduced pressure and water was added, and then the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (25.88 g) as a yellow oily substance. The solvent was distilled off under reduced pressure and water was added the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine dried over anhydrous sodium sulfate The solvent was distilled off under reduced pressure