2-氨基-5-溴-N-乙基苯甲酰胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Prepared analogously to Compound 3D replacing diethylamine with ethylamine to afford 1.41 g of the title product (70%). 1H NMR (400 MHz, CD3OD) δ 7.55 (d, J=2.3 Hz, 1H), 7.25 (dd, J=2.4, 8.7 Hz, 1H), 6.67 (d, J=8.8 Hz, 1H), 3.32-3.38 (m, 2H), 1.20 (t, J=7.3 Hz, 3H). MS (ESI): m/z 243.33 [M+H]+. UPLC: tR=0.98 min (UPLC-SQD: analytical—2 min).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Prepared analogously to Compound 3C replacing Compound 3D with 2-amino-5-bromo-N-ethylbenzamide (Compound 9D, 1.40 g, 5.77 mmol) to afford 729 mg of the title compound (37%). 1H NMR (400 MHz, CD3OD) δ 7.87 (s, 1H), 7.76 (d, J=0.5 Hz, 1H), 7.63 (d, J=2.0 Hz, 1H), 7.34-7.41 (m, 1H), 6.77 (d, J=8.3 Hz, 1H), 4.25 (t, J=6.9 Hz, 2H), 3.54 (t, J=6.2 Hz, 2H), 3.38 (q, J=7.2 Hz, 2H), 2.06 (quin, J=6.6 Hz, 2H), 1.23 (t, J=7.2 Hz, 3H). MS (ESI): m/z 289.32 [M+H]+. UPLC: tR=0.63 min (UPLC-SQD: analytical—2 min).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Prepared analogously to Compound 3C replacing Compound 3D with 2-amino-5-bromo-N-ethylbenzamide (Compound 9D, 1.40 g, 5.77 mmol) to afford 729 mg of the title compound (37%). 1H NMR (400 MHz, CD3OD) δ 7.87 (s, 1H), 7.76 (d, J=0.5 Hz, 1H), 7.63 (d, J=2.0 Hz, 1H), 7.34-7.41 (m, 1H), 6.77 (d, J=8.3 Hz, 1H), 4.25 (t, J=6.9 Hz, 2H), 3.54 (t, J=6.2 Hz, 2H), 3.38 (q, J=7.2 Hz, 2H), 2.06 (quin, J=6.6 Hz, 2H), 1.23 (t, J=7.2 Hz, 3H). MS (ESI): m/z 289.32 [M+H]+. UPLC: tR=0.63 min (UPLC-SQD: analytical—2 min).