b-AMino-cyclobutaneethanol HCl

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 1-hydroxymethyl-1-cyclobutylmethylamine (5.75 g, 0.05 mol), 2-amino-4,6-dichloropyrimidine (8.20 g, 0.05 mol), ethanol (200 ml) and triethylamine (20 ml) was refluxed for one day. The solvent was distilled away under reduced pressure. The residue was washed with water, dried and recrystallized from acetone to give colorless prism crystals (11.2 g, 92.3%), m.p. 192-194° C. (acetone). was refluxed for one day The solvent was distilled away under reduced pressure The residue was washed with water dried recrystallized from acetone