(R) -1-(2-三氟甲基苯基)乙醇

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In a similar manner as described for example B31, 441 mg of methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate, 300 mg of (1R)-1-[2-(trifluoromethyl)phenyl]ethanol, 672 mg of triphenylphosphine (polymer bound, ˜3 mmol/g) and 484 mg of di-tert-butyl azodicarboxylate in 12 ml anhydrous dichloromethane yield the title compound.