tert-butyl N-(3-fluoropropyl)-N-[(3S)-pyrrolidin-3-yl]carbamate

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of (S)-benzyl 3-(tert-butoxycarbonyl(3-fluoropropyl)amino)pyrrolidine-1-carboxylate (611 mg, 1.6 mmol) in methanol (6.5 mL) was added ammonium formate (1.1 g, 18 mmol) followed palladium on carbon (10% w/w, 479 mg, 0.22 mmol). The reaction mixture was stirred at ambient temperature under a balloon of hydrogen for 1 hour, then degassed and filtered over a pad of celite. The filtrate was concentrated in vacuo to afford a residue, which was used in the next step without any further purification. degassed filtered over a pad of celite The filtrate was concentrated in vacuo to afford a residue, which was used in the next step without any further purification

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of (S)-benzyl 3-(tert-butoxycarbonyl(3-fluoropropyl)amino)pyrrolidine-1-carboxylate (611 mg, 1.6 mmol) in methanol (6.5 mL) was added ammonium formate (1.1 g, 18 mmol) followed palladium on carbon (10% w/w, 479 mg, 0.22 mmol). The reaction mixture was stirred at ambient temperature under a balloon of hydrogen for 1 hour, then degassed and filtered over a pad of celite. The filtrate was concentrated in vacuo to afford a residue, which was used in the next step without any further purification. degassed filtered over a pad of celite The filtrate was concentrated in vacuo to afford a residue, which was used in the next step without any further purification

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of (S)-benzyl 3-(tert-butoxycarbonyl(3-fluoropropyl)amino)pyrrolidine-1-carboxylate (611 mg, 1.6 mmol) in methanol (6.5 mL) was added ammonium formate (1.1 g, 18 mmol) followed palladium on carbon (10% w/w, 479 mg, 0.22 mmol). The reaction mixture was stirred at ambient temperature under a balloon of hydrogen for 1 hour, then degassed and filtered over a pad of celite. The filtrate was concentrated in vacuo to afford a residue, which was used in the next step without any further purification. degassed filtered over a pad of celite The filtrate was concentrated in vacuo to afford a residue, which was used in the next step without any further purification