3-吲哚丙烯酸乙酯

反应条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of the product of Step 2 (20 g) in 300 mL of DMF was added 30 g of BrCH2CO2-t-Bu and 65 g of Cs2CO3. The reaction mixture was stirred at 60° C. for 24 h, and was then diluted with 300 ml of acetone and filtered. The filtrate was concentrated and the residue was purified by silica gel chromatography eluted with 1:2 EtOAc/hexane to give 30 g of the title compound as a syrup. filtered The filtrate was concentrated the residue was purified by silica gel chromatography eluted with 1:2 EtOAc/hexane

反应条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of the product of Step 2 (20 g) in 300 mL of DMF was added 30 g of BrCH2CO2-t-Bu and 65 g of Cs2CO3. The reaction mixture was stirred at 60° C. for 24 h, and was then diluted with 300 ml of acetone and filtered. The filtrate was concentrated and the residue was purified by silica gel chromatography eluted with 1:2 EtOAc/hexane to give 30 g of the title compound as a syrup. filtered The filtrate was concentrated the residue was purified by silica gel chromatography eluted with 1:2 EtOAc/hexane

反应条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a 0.1 M DMF solution of ethyl (2E)-3-(1H-indol-2-yl) acrylate from Step 2 was added 1.4 equiv. of BrCH2CO2-t-Bu and 2.1 equiv. of Cs2CO3. The reaction mixture was stirred at 60° C. for 24 h, and was then diluted with an equal volume of acetone and filtered. The filtrate was concentrated and the residue was purified by silica gel chromatography eluted with EtOAc/Hex (1:2) to give the title compound (98%) as a syrup. filtered The filtrate was concentrated the residue was purified by silica gel chromatography eluted with EtOAc/Hex (1:2)

反应条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a 0.1 M DMF solution of ethyl (2E)-3-(1H-indol-2-yl) acrylate from Step 2 was added 1.4 equiv. of BrCH2CO2-t-Bu and 2.1 equiv. of Cs2CO3. The reaction mixture was stirred at 60° C. for 24 h, and was then diluted with an equal volume of acetone and filtered. The filtrate was concentrated and the residue was purified by silica gel chromatography eluted with EtOAc/Hex (1:2) to give the title compound (98%) as a syrup. filtered The filtrate was concentrated the residue was purified by silica gel chromatography eluted with EtOAc/Hex (1:2)

反应条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of the product of Step 2 (20 g) in 300 mL of DMF was added 30 g of BrCH2CO2-t-Bu and 65 g of Cs2CO3. The reaction mixture was stirred at 60° C. for 24 h, and was then diluted with 300 ml of acetone and filtered. The filtrate was concentrated and the residue was purified by silica gel chromatography eluted with 1:2 EtOAc/hexane to give 30 g of the title compound as a syrup. filtered The filtrate was concentrated the residue was purified by silica gel chromatography eluted with 1:2 EtOAc/hexane

反应条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a 0.1 M DMF solution of ethyl (2E)-3-(1H-indol-2-yl) acrylate from Step 2 was added 1.4 equiv. of BrCH2CO2-t-Bu and 2.1 equiv. of Cs2CO3. The reaction mixture was stirred at 60° C. for 24 h, and was then diluted with an equal volume of acetone and filtered. The filtrate was concentrated and the residue was purified by silica gel chromatography eluted with EtOAc/Hex (1:2) to give the title compound (98%) as a syrup. filtered The filtrate was concentrated the residue was purified by silica gel chromatography eluted with EtOAc/Hex (1:2)