6-氯-2,3-二氟苄基

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was prepared from methyl 2-(tert-butoxy)-2-(6-methyl-4-(p-tolyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)acetate and 2-(bromomethyl)-1-chloro-3,4-difluorobenzene in a manner similar to that described in Example 25 as a yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm=7.68-7.62 (m, 1 H), 7.44-7.39 (m, 1 H), 7.35 (d, J=7.8 Hz, 2 H), 7.31-7.25 (m, 1 H), 7.12 (d, J=3.5 Hz, 1 H), 6.96 (dd, J=8.4, 10.5 Hz, 1 H), 6.29 (d, J=3.5 Hz, 1 H), 5.64-5.52 (m, 3 H), 2.75 (s, 3 H), 2.48 (s, 3 H), 0.96 (s, 9 H); LCMS (m/z) ES+=513 (M+1).