2,2-二甲基环戊烷-1,3-二胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Sodium (177 mg, 7.68 mmol) was added to a solution of crude 2,2-dimethylcyclopentane-1,3-dione dioxime (120 mg) in n-propanol (10 mL) at 80° C. The mixture was heated to reflux for 2 h, cooled to room temperature and poured into brine (30 mL). The mixture was extracted with dichloromethane (3×50 mL). The combined organic extracts were dried (MgSO4), filtered and concentrated to give crude 2,2-dimethylcyclopentane-1,3-diamine (85 mg), which was used in the next step without purification. The mixture was heated to reflux for 2 h The mixture was extracted with dichloromethane (3×50 mL) The combined organic extracts were dried (MgSO4) filtered concentrated