2-(1-甲氧基环丙基)乙-1-胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A 0° C. solution of 2-(1-methoxycyclopropyl)ethanamine (0.361 g, 2.413 mmol) in THF (15 mL) was treated drop-wise with 2-chloroethyl isocyanate (0.226 mL, 2.65 mmol), allowed to warm to RT, stirred overnight, then concentrated to dryness. The residue was treated with toluene and concentrated to dryness (twice) to afford 1-(2-chloroethyl)-3-(2-(1-methoxycyclopropyl)ethyl)urea (429 mg, 81%) as a yellow oil. MS (ESI) m/z: 221.1 (M+H+). concentrated to dryness The residue was treated with toluene concentrated to dryness (twice)