(3aS,6aR)-rel-1,2,3,3a,4,5,6,6a-八氢环戊二烯并[c]吡咯

反应条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2 g of cis-octahydrocyclopenta[c]pyrrole are dissolved in 10 mL of ethanol in a flask. The solution is cooled to 0° C., and there are then added 1.64 mL of concentrated hydrochloric acid solution (11M). The reaction mixture is stirred at 20° C. for 30 minutes before being concentrated under reduced pressure. The reaction mixture is stirred in methyl tert-butyl ether at 0° C. The product is isolated by filtration in the form of a solid in a yield of 83% and with a chemical purity of 99%. before being concentrated under reduced pressure The reaction mixture is stirred in methyl tert-butyl ether at 0° C The product is isolated by filtration in the form of a solid in a yield of 83% and with a chemical purity of 99%

反应条件: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 15.2 kg of 4-(3-chloropropoxy)benzamide, 40.28 kg of cis-octahydrocyclopenta[c]pyrrole in 30% aqueous solution, 63.84 kg of water, 21.48 kg of isopropanol and 14.39 kg of triethylamine are introduced into a reactor. The reaction mixture is stirred and heated at reflux until all the starting material has been consumed. The reaction mixture is then cooled to 20° C., before being filtered and washed with a mixture of isopropanol and water. The product is obtained in the form of a powder in a yield of 83% and with a chemical purity of 97%. heated at reflux until all the starting material has been consumed before being filtered washed with a mixture of isopropanol and water The product is obtained in the form of a powder in a yield of 83% and with a chemical purity of 97%

反应条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2 g of cis-octahydrocyclopenta[c]pyrrole are dissolved in 10 mL of ethanol in a flask. The solution is cooled to 0° C., and there are then added 1.64 mL of concentrated hydrochloric acid solution (11M). The reaction mixture is stirred at 20° C. for 30 minutes before being concentrated under reduced pressure. The reaction mixture is stirred in methyl tert-butyl ether at 0° C. The product is isolated by filtration in the form of a solid in a yield of 83% and with a chemical purity of 99%. before being concentrated under reduced pressure The reaction mixture is stirred in methyl tert-butyl ether at 0° C The product is isolated by filtration in the form of a solid in a yield of 83% and with a chemical purity of 99%

反应条件: temp:20.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 15.2 kg of 4-(3-chloropropoxy)benzamide, 40.28 kg of cis-octahydrocyclopenta[c]pyrrole in 30% aqueous solution, 63.84 kg of water, 21.48 kg of isopropanol and 14.39 kg of triethylamine are introduced into a reactor. The reaction mixture is stirred and heated at reflux until all the starting material has been consumed. The reaction mixture is then cooled to 20° C., before being filtered and washed with a mixture of isopropanol and water. The product is obtained in the form of a powder in a yield of 83% and with a chemical purity of 97%. heated at reflux until all the starting material has been consumed before being filtered washed with a mixture of isopropanol and water The product is obtained in the form of a powder in a yield of 83% and with a chemical purity of 97%