2-异丙基环戊酮

反应条件: temp:120.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 1.1 g of 85% strength aqueous potassium hydroxide solution and 100 ml of water was charged to a 0.31 stainless-steel autoclave, and then 25.2 g of 2-isopropylcyclopentanone and 28.1 g of 4-chlorobenzaldehyde were added, and the mixture was heated to 120° C. under the intrinsic pressure and subsequently stirred at this temperature (intrinsic pressure 1 bar) for 5 hours. After cooling to room temperature, the suspension was filtered with suction and the product was washed to neutrality with water and then dried in a vacuum oven at 55° C. In this way 46.8 g of 2-isopropyl-5-(4-chlorobenzylidene)-cyclopentanone (98.7% pure) were obtained. This corresponds to a yield of 93% of theory. After cooling to room temperature the suspension was filtered with suction the product was washed dried in a vacuum oven at 55° C