3-氯丙烯基-1-硼酸

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In a 4 mL vial were mixed (E)-2-(3-chloroprop-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (0.195 ml, 0.988 mmol) and potassium carbonate (273 mg, 1.975 mmol) in anhydrous acetonitrile (2 ml). Benzylmethylamine (0.166 ml, 1.284 mmol) was added to this mixture, and the reaction was stirred vigorously overnight at room temperature. The reaction was diluted with ethyl acetate and washed with water and brine. The organic layer was dried with sodium sulfate, decanted, and concentrated to provide the title compound. washed with water and brine The organic layer was dried with sodium sulfate decanted concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: In a 4 mL vial were mixed (E)-2-(3-chloroprop-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (0.195 ml, 0.988 mmol) and potassium carbonate (273 mg, 1.975 mmol) in anhydrous acetonitrile (2 ml). Benzylmethylamine (0.166 ml, 1.284 mmol) was added to this mixture, and the reaction was stirred vigorously overnight at room temperature. The reaction was diluted with ethyl acetate and washed with water and brine. The organic layer was dried with sodium sulfate, decanted, and concentrated to provide the title compound. washed with water and brine The organic layer was dried with sodium sulfate decanted concentrated

实验步骤: 投料: 往三口瓶加入SM1（54.1g，0.26mol）、DMF（10V）、SM4（1.2eq）和碳酸钾（3.0eq）； 反应液室温搅拌过夜； TLC显示反应完全； 反应液倒入水中，用EA萃取，合并有机相，浓缩得粗品； 粗品经柱层析纯化得无色油状物产品P1（60g，90%纯）

实验步骤: 投料: 往三口瓶加入SM1（10g，1.0eq）、DMF（100mL）、SM4（1.2eq）和碳酸钾（3.0eq）； 反应液室温搅拌过夜； TLC显示反应完全； 反应液倒入水中，用EA萃取，合并有机相，浓缩得粗品； 粗品经柱层析纯化得无色油状物产品P1（8.1g，96%纯）

实验步骤: 投料: 往三口瓶加入SM1（4.3g，20.6mmol）、DMF（90mL）、SM2（1.2eq）和碳酸钾（3.0eq）； 反应液室温搅拌过夜； TLC显示反应完全； 反应液倒入水中，用EA萃取，合并有机相，浓缩得粗品； 粗品经柱层析纯化得无色油状物产品P1（4.6g，95%纯）

实验步骤: 投料: 往单口瓶加入SM1（50mg，0.247mmol）、DMF（1mL）、SM2（1.05eq）和碳酸钾（3.0eq），室温搅拌； TLC显示有产品，但和SM2重叠，难以纯化；

实验步骤: 投料: 往三口瓶加入SM1（4.3g，20.6mmol）、DMF（90mL）、SM2（1.2eq）和碳酸钾（3.0eq）； 反应液室温搅拌过夜； TLC显示反应完全； 反应液倒入水中，用EA萃取，合并有机相，浓缩得粗品； 粗品经柱层析纯化得无色油状物产品P1（1.9g，90%纯）和P2（3.0g，95%纯）

实验步骤: 投料: 往单口瓶加入SM1（750mg，3.50mmol）、DMF（1mL）、SM2（1.2eq）和碳酸钾（3.0eq）； 反应液室温搅拌过夜； TLC显示反应完全； 反应液倒入水中，用EA萃取，合并有机相，浓缩得粗品； 粗品经柱层析纯化得无色油状物产品600mg

实验步骤: 投料: 往单口瓶加入SM1（50mg，0.241mmol）、DMF（1mL）、SM2（1.2eq）和碳酸钾（3.0eq）； 反应液室温搅拌过夜； TLC显示反应完全； 反应液倒入水中，用EA萃取，合并有机相，浓缩得粗品； 粗品经TLC纯化得无色油状物产品35mg

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of (E)-2-(3-chloroprop-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1 g, 4.94 mmol) in acetonitrile (10 mL) was treated with potassium carbonate (1.366 g, 9.88 mmol) and pyrrolidine (0.531 mL, 6.42 mmol). The suspension was stirred at ambient temperature for 20 hours. The reaction mixture was filtered and the filtrate was concentrated on a rotary evaporator to provide the title compound. MS ESI(+) m/z 238.2 [M+H]+. The reaction mixture was filtered the filtrate was concentrated on a rotary evaporator

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of (E)-2-(3-chloroprop-1-enyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1 g, 4.94 mmol) in acetonitrile (10 mL) was treated with potassium carbonate (1.366 g, 9.88 mmol) and pyrrolidine (0.531 mL, 6.42 mmol). The suspension was stirred at ambient temperature for 20 hours. The reaction mixture was filtered and the filtrate was concentrated on a rotary evaporator to provide the title compound. MS ESI(+) m/z 238.2 [M+H]+. The reaction mixture was filtered the filtrate was concentrated on a rotary evaporator

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of (E)-3-chloroprop-1-enylboronic acid (5 g, 41 mmol), pinacol (4.9 g, 41 mmol), and magnesium sulfate (15 g, 120 mmol) in methylene chloride (100 mL) was stirred at room temperature for 18 h. The reaction mixture was filtered through silica gel and the filter cake was washed with methylene chloride. The filtrate was concentrated to afford the desired product (4.8 g, 60%) as a colorless oil: ESI MS m/z 203 [C9H16BClO2+H]+. The reaction mixture was filtered through silica gel the filter cake was washed with methylene chloride The filtrate was concentrated