(3S)-3-氨基丁酸叔丁酯

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1,1-dimethylethyl (3S)-3-aminobutanoate using methods similar to Example 563 to provide an orange solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.25 (d, J=6.74 Hz, 3 H), 1.39 (s, 9 H), 1.52-1.67 (m, 4 H), 1.99-2.11 (m, 2 H), 2.52-2.58 (m, 2 H), 3.19-3.30 (m, 2 H), 3.49 (t, J=6.84 Hz, 2 H), 4.16 (s, 2 H), 4.35-4.42 (m, 3 H), 7.11-7.17 (m, 2 H), 7.41 (m, 2 H), 8.20 (d, J=1.47 Hz, 1 H), 8.57 (d, J=1.68 Hz, 1 H), 10.41 (d, J=8.21 Hz, 1 H), 17.06 (d, J=5.26 Hz, 1 H); ES+ MS: 581 (M+H+). to provide an orange solid

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: This compound was prepared from ethyl 7-[(4-fluorophenyl)methyl]-4-hydroxy-2-oxo-1-[2-(2-oxo-1-piperidinyl)ethyl]-1,2-dihydro-1,5-naphthyridine-3-carboxylate and 1,1-dimethylethyl (3S)-3-aminobutanoate using methods similar to Example 563 to provide an orange solid: 1H NMR (300 MHz, DMSO-d6) δ ppm 1.25 (d, J=6.74 Hz, 3 H), 1.39 (s, 9 H), 1.52-1.67 (m, 4 H), 1.99-2.11 (m, 2 H), 2.52-2.58 (m, 2 H), 3.19-3.30 (m, 2 H), 3.49 (t, J=6.84 Hz, 2 H), 4.16 (s, 2 H), 4.35-4.42 (m, 3 H), 7.11-7.17 (m, 2 H), 7.41 (m, 2 H), 8.20 (d, J=1.47 Hz, 1 H), 8.57 (d, J=1.68 Hz, 1 H), 10.41 (d, J=8.21 Hz, 1 H), 17.06 (d, J=5.26 Hz, 1 H); ES+ MS: 581 (M+H+). to provide an orange solid