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C1CC1NCC2=CC=CC=C2Cl产品信息
(2-氯苄基)(环丙基)胺（CAS 16357-33-8）的产品身份、结构标识及相关反应资料，供化学中间体检索、研发和采购评估使用。
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合成路线数据
9 条反应 · 9 篇文献
反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Synthesized according to typical procedures H and E from bicyclononene BN10 and (2-chlorobenzyl)cyclopropylamine. LC-MS: Rt=0.90; ES+: 638.22. Synthesized
来源 ID: ord-5fb8eae6519d403584c1ba3e615159ff反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Synthesized according to typical procedures B and D from 2-chlorobenzoyl chloride and cyclopropylamine. Synthesized
来源 ID: ord-f42ef03eb5ba4c0389e0f84184c71360反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-4179fcf3e57140428d6231c82a2c987c反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Synthesized according to typical procedures H and E from bicyclononene BN10 and (2-chlorobenzyl)cyclopropylamine. LC-MS: Rt=0.90; ES+: 638.22. Synthesized
来源 ID: ord-5fb8eae6519d403584c1ba3e615159ff反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Synthesized according to typical procedures B and D from 2-chlorobenzoyl chloride and cyclopropylamine. Synthesized
来源 ID: ord-f42ef03eb5ba4c0389e0f84184c71360反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Synthesized according to typical procedures H and E from bicyclononene BN10 and (2-chlorobenzyl)cyclopropylamine. LC-MS: Rt=0.90; ES+: 638.22. Synthesized
来源 ID: ord-5fb8eae6519d403584c1ba3e615159ff反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Synthesized according to typical procedures B and D from 2-chlorobenzoyl chloride and cyclopropylamine. Synthesized
来源 ID: ord-f42ef03eb5ba4c0389e0f84184c71360反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-4179fcf3e57140428d6231c82a2c987c反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: To a stirred, ice-cooled mixture of (3S*,5R*)-5-tert-butoxycarbonylamino-piperidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester (233.3 mg, 0.5 mmol), (2-chlorobenzyl)-cyclopropylamine (99.9 mg, 0.55 mmol) and N-ethyldiisopropylamine (685 μL, 4 mmol) in dimethylacetamide (2.5 mL), propylphosphonic anhydride solution (˜50% in DMF, 480 μL, ˜0.75 mmol) is added. The reaction mixture is stirred for 14 h at RT, diluted with ethyl acetate and washed twice with an aqueous NaHCO3 solution. The combined organic layers are dried (Na2SO4) and evaporated in vacuo, and the residue is purified by preparative HPLC (C18 column, 10-100% CH3CN+0.1% TFA/H2O+0.1% TFA, 20 min, flow 20 mL/min). The combined pure fractions are treated with Na2CO3, CH3CN is removed in vacuo, and the residual aqueous phase is extracted three times with CH2Cl2. The combined organic layers are dried (Na2SO4) and evaporated to afford the title compound as a white amorphous solid. MS: 630.7 [M+H]+; tR (HPLC, Nucleosil C18; 5-100% CH3CN+0.1% TFA/H2O+0.1% TFA for 8 min, then 100% CH3CN+0.1% TFA for 2 min, flow 1.5 ml/min): 8.24 min. To a stirred, ice-cooled is added washed twice with an aqueous NaHCO3 solution The combined organic layers are dried (Na2SO4) evaporated in vacuo the residue is purified by preparative HPLC (C18 column, 10-100% CH3CN+0.1% TFA/H2O+0.1% TFA, 20 min, flow 20 mL/min) The combined pure fractions are treated with Na2CO3, CH3CN is removed in vacuo the residual aqueous phase is extracted three times with CH2Cl2 The combined organic layers are dried (Na2SO4) evaporated
来源 ID: ord-a01a058f9de744ffa0aa49a5fc115cccPubChem References
以下资料来自该化合物的公开数据库参考记录。