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2-溴乙基甲基砜（CAS 16523-02-7）的产品身份、结构标识及相关反应资料，供化学中间体检索、研发和采购评估使用。
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7 条反应 · 7 篇文献
反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-1c57d209367b4769b5be40a75cc6b8aa反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Potassium carbonate (67 mg, 0.486 mmol) and 1-bromo-2-(methylsulfonyl)ethane (68 mg, 0.365 mmol) are added to a solution of 4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile (example 1, 100 mg, 0.243 mmol) in N,N-dimethylformamide (3 mL). The mixture is heated at 50° C. for 3 d and then purified by reversed phase HPLC (first purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% NH3; second purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% TFA). Yield: 22 mg; ESI mass spectrum [M+H]+=518; Retention time HPLC: 0.86 min (Z011_S03). purified by reversed phase HPLC (first purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% NH3; second purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% TFA) 0.86 min (Z011_S03)
来源 ID: ord-bdf6826932084b249438b8eff81b5e93反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Potassium carbonate (67 mg, 0.486 mmol) and 1-bromo-2-(methylsulfonyl)ethane (68 mg, 0.365 mmol) are added to a solution of 4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile (example 1, 100 mg, 0.243 mmol) in N,N-dimethylformamide (3 mL). The mixture is heated at 50° C. for 3 d and then purified by reversed phase HPLC (first purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% NH3; second purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% TFA). Yield: 22 mg; ESI mass spectrum [M+H]+=518; Retention time HPLC: 0.86 min (Z011_S03). purified by reversed phase HPLC (first purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% NH3; second purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% TFA) 0.86 min (Z011_S03)
来源 ID: ord-bdf6826932084b249438b8eff81b5e93反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 300 mg (0.567 mmol) of the compound from example 93A were reacted in analogy to the method in example 83A with 2-bromoethyl methyl sulfone. 490 mg (100% of theory, 73% purity) of the title compound were obtained.
来源 ID: ord-86c72874a33e49dbac243f64c5e91045反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-1c57d209367b4769b5be40a75cc6b8aa反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Potassium carbonate (67 mg, 0.486 mmol) and 1-bromo-2-(methylsulfonyl)ethane (68 mg, 0.365 mmol) are added to a solution of 4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile (example 1, 100 mg, 0.243 mmol) in N,N-dimethylformamide (3 mL). The mixture is heated at 50° C. for 3 d and then purified by reversed phase HPLC (first purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% NH3; second purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% TFA). Yield: 22 mg; ESI mass spectrum [M+H]+=518; Retention time HPLC: 0.86 min (Z011_S03). purified by reversed phase HPLC (first purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% NH3; second purification: Waters Xbridge™-C18, gradient of acetonitrile in water, 0.1% TFA) 0.86 min (Z011_S03)
来源 ID: ord-bdf6826932084b249438b8eff81b5e93反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 300 mg (0.567 mmol) of the compound from example 93A were reacted in analogy to the method in example 83A with 2-bromoethyl methyl sulfone. 490 mg (100% of theory, 73% purity) of the title compound were obtained.
来源 ID: ord-86c72874a33e49dbac243f64c5e91045PubChem References
以下资料来自该化合物的公开数据库参考记录。