2,5,8,11,14,17,20-七氧杂二十二烷-22-胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: According to the procedure described in Ex. 2, 2.3 g of 2,3,4,5-tetraiodopyrrol-1-acetic acid ethyl ester (prepared according to the procedure described in Ex. 1) (0.00457 mol) and 23.27 g of compound B, 3,6,9,12,15,18,21-heptaoxadocosylamine, (0.0685 mol) are reacted. 3.82 g of N-[3,6,9,12,15,18,21-heptaoxadocos-1-y1]-2,3,4,5-tetraiodopyrrol-1-acetamide (0.0040 mol) are obtained.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a suspension of 4.38 g of 2-(1-imidazolylcarbonylamino)-6-methyl-4[1H]-pyrimidinone 1A (0.02 mol) in 200 ml of ethyl acetate were added 7.4 g of 2,5,8,11,14,17,20 heptaoxadocosan-22-amine (0.0218 mol). The reaction mixture was refluxed for 12 hours. The mixture was then allowed to return to room temperature, and was evaporated under reduced pressure. The residue was taken up in acetone (50 ml) and then filtered to remove the imidazole. The filtrate was evaporated under reduced pressure and then taken up again in 50 ml of acetone and filtered. The filtrate was evaporated under reduced pressure. 5.9 g of the expected product were thus obtained in the form of a pasty oil, in a yield of 60%. 1H and 13C NMR spectra compliant. The reaction mixture was refluxed for 12 hours to return to room temperature was evaporated under reduced pressure filtered to remove the imidazole The filtrate was evaporated under reduced pressure filtered The filtrate was evaporated under reduced pressure

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: According to the procedure described in Ex. 2, 2.3 g of 2,3,4,5-tetraiodopyrrol-1-acetic acid ethyl ester (prepared according to the procedure described in Ex. 1) (0.00457 mol) and 23.27 g of compound B, 3,6,9,12,15,18,21-heptaoxadocosylamine, (0.0685 mol) are reacted. 3.82 g of N-[3,6,9,12,15,18,21-heptaoxadocos-1-y1]-2,3,4,5-tetraiodopyrrol-1-acetamide (0.0040 mol) are obtained.