7-氮杂双环[2.2.1]庚烷-2-基甲醇;盐酸盐

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To the title compound of Step A in DMF was added TEA, 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid and HATU. After 18 h, H2O was added and the mix extracted with EtOAc (2×). The combined organics were washed with brine and dried (Na2SO4). Silica gel chromatography (1-7% 2M NH3/MeOH in DCM) gave the title compound (371 mg, 46%). MS (ESI) mass calcd. for C17H20N4O2, 312.2; m/z found 313.2 [M+H]+. the mix extracted with EtOAc (2×) The combined organics were washed with brine dried (Na2SO4)