2-(4-氯苯基)-1-(吡咯烷-1-基)乙烷-1-酮

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 16.8 g (0.075 mol) of 2-(4-chloro-phenyl)-1-pyrrolidin-1-yl-ethanone are dissolved in 175 ml dimethylsulphoxide and after the addition of 8.9 g (0.08 mol) of potassium tert.butoxide stirred for 15 minutes at ambient temperature. After the addition of 18.1 ml (0.085 mol) of ethyl iodoacetate the reaction mixture is stirred for 45 hours at ambient temperature. The solution is poured onto ice water and extracted with ethyl acetate. The combined organic extracts are washed with sodium chloride solution, dried and concentrated by evaporation. The residue is chromatographed on silica gel, initially eluting with petroleum ether and later with petroleum ether/ethyl acetate (8:2 and 1:1). The desired fractions are combined and concentrated by evaporation. is stirred for 45 hours at ambient temperature The solution is poured onto ice water extracted with ethyl acetate The combined organic extracts are washed with sodium chloride solution dried concentrated by evaporation The residue is chromatographed on silica gel initially eluting with petroleum ether and later with petroleum ether/ethyl acetate (8:2 and 1:1) concentrated by evaporation

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 16.8 g (0.075 mol) of 2-(4-chlorophenyl)-1-(pyrrolidin-1-yl)-ethanone are dissolved in 175 ml dimethylsulphoxide and after the addition of 8.9 g (0.08 mol) of potassium tert.butoxide, stirred for 15 minutes at ambient temperature. After the addition of 18.1 ml (0.085 mol) of ethyl iodoacetate the reaction mixture is stirred for 45 hours at ambient temperature. The solution is poured onto ice water and extracted with ethyl acetate. The combined organic extracts are washed with sodium chloride solution, dried and evaporated down. The residue is chromatographed on silica gel, eluting first with petroleum ether and later with petroleum ether/ethyl acetate (8:2 and 1:1). The desired fractions are combined and evaporated down. is stirred for 45 hours at ambient temperature The solution is poured onto ice water extracted with ethyl acetate The combined organic extracts are washed with sodium chloride solution dried evaporated down The residue is chromatographed on silica gel eluting first with petroleum ether and later with petroleum ether/ethyl acetate (8:2 and 1:1) evaporated down