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C1=CC=C(C=C1)S(=O)(=O)CCCCl产品信息
3-chloropropylsulfonylbenzene（CAS 19432-96-3）的产品身份、结构标识及相关反应资料，供化学中间体检索、研发和采购评估使用。
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12 条反应 · 12 篇文献
反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-e530eff72b2c447aa9172de0e5a5128f反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-e1a37fed4f42486a85fb79b2754e3979反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-4910c82bb2c34a60813c2628d070c81e反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride and 3-phenylsulfonylpropyl chloride were reacted and treated in the same manner as in Example 199 to give 4-amino-5-chloro-2-methoxy-N-((1-(3-(phenylsulfonyl)propyl)piperidin-4-yl)methyl)-benzamide. treated in the same manner as in Example 199
来源 ID: ord-97cd001a45d44363ac71c55ff722d911反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-e530eff72b2c447aa9172de0e5a5128f反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-e530eff72b2c447aa9172de0e5a5128f反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of 66.55 g (0.3052 mole) of 3-chloropropylphenyl sulfone (prepared by reacting m-chloroperoxybenzoic acid and 3-chloropropyl phenylsulfide in methylene chloride) in 200 ml of isopropylamine was heated at 100° C. overnight in a bomb. The isopropylamine was removed by rotary evaporation and the residue partitioned between chloroform and water. The chloroform layer was extracted with 1N sulfuric acid. The acidic layer was made alkaline and extracted with chloroform. The combined chloroform extract was evaporated to give an oil, the free base of the title compound. The oil was converted to the hydrochloride salt by reacting with ethereal hydrogen chloride. Recrystallization of the precipitated salt from methanol-diethyl ether gave 48.04 g (65.3%) of white crystalline powder, m.p. 185°-186° C. The isopropylamine was removed by rotary evaporation the residue partitioned between chloroform and water The chloroform layer was extracted with 1N sulfuric acid extracted with chloroform The combined chloroform extract was evaporated to give an oil
来源 ID: ord-42a70ce1422f439ebb9c5d10762eab4f反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of 66.55 g (0.3052 mole) of 3-chloropropylphenyl sulfone (prepared by reacting m-chloroperoxybenzoic acid and 3-chloropropyl phenylsulfide in methylene chloride) in 200 ml of isopropylamine was heated at 100° C. overnight in a bomb. The isopropylamine was removed by rotary evaporation and the residue partitioned between chloroform and water. The chloroform layer was extracted with 1N sulfuric acid. The acidic layer was made alkaline and extracted with chloroform. The combined chloroform extract was evaporated to give an oil, the free base of the title compound. The oil was converted to the hydrochloride salt by reacting with ethereal hydrogen chloride. Recrystallization of the precipitated salt from methanol-diethyl ether gave 48.04 g (65.3%) of white crystalline powder, m.p. 185°-186° C. The isopropylamine was removed by rotary evaporation the residue partitioned between chloroform and water The chloroform layer was extracted with 1N sulfuric acid extracted with chloroform The combined chloroform extract was evaporated to give an oil
来源 ID: ord-42a70ce1422f439ebb9c5d10762eab4f反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 4-Amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide dihydrochloride and 3-phenylsulfonylpropyl chloride were reacted and treated in the same manner as in Example 199 to give 4-amino-5-chloro-2-methoxy-N-((1-(3-(phenylsulfonyl)propyl)piperidin-4-yl)methyl)-benzamide. treated in the same manner as in Example 199
来源 ID: ord-97cd001a45d44363ac71c55ff722d911反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A solution of 66.55 g (0.3052 mole) of 3-chloropropylphenyl sulfone (prepared by reacting m-chloroperoxybenzoic acid and 3-chloropropyl phenylsulfide in methylene chloride) in 200 ml of isopropylamine was heated at 100° C. overnight in a bomb. The isopropylamine was removed by rotary evaporation and the residue partitioned between chloroform and water. The chloroform layer was extracted with 1N sulfuric acid. The acidic layer was made alkaline and extracted with chloroform. The combined chloroform extract was evaporated to give an oil, the free base of the title compound. The oil was converted to the hydrochloride salt by reacting with ethereal hydrogen chloride. Recrystallization of the precipitated salt from methanol-diethyl ether gave 48.04 g (65.3%) of white crystalline powder, m.p. 185°-186° C. The isopropylamine was removed by rotary evaporation the residue partitioned between chloroform and water The chloroform layer was extracted with 1N sulfuric acid extracted with chloroform The combined chloroform extract was evaporated to give an oil
来源 ID: ord-3899e2d65d6d4b47ba44772811d58aca反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-e1a37fed4f42486a85fb79b2754e3979反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-4910c82bb2c34a60813c2628d070c81ePubChem References
以下资料来自该化合物的公开数据库参考记录。