2,3,4-三氟苯甲醚

实验步骤: 投料: 将原料溶解在THF50 ml，再加入碳酸钾（23g,3.0 eq），搅拌30 min。再加入碘甲烷（28.74g，1.5 eq）,升温60 ℃，反应4-5小时，TLC监测反应完全（PE/EA=10/1），过滤，ea冲洗，由白色滤液变成黄色滤液，干燥得黄色固体。

实验步骤: 投料: 将二异丙胺溶解在THF（90 ml）中，冷却到-78℃，滴加n-BuLi(28 ml,1.2 eq)，反应1-2 h,再加入1,2,3-trifluoro-4-methoxybenzene（9 g,1.0 eq）反应1-2 h,再加入干冰缓慢（干冰表面有水可以用四氢呋喃冲洗后加入，缓慢加入容易冲料。）回到室温反应12H.TLC检测反应完全（DCM/MEOH=10/1）,将反应液倒入1N的盐酸水溶液中，再用EA萃取，浓缩干燥得白色固体7.2g.

实验步骤: 投料: 将二异丙胺溶解在THF（90 ml）中，冷却到-78℃，滴加n-BuLi(13.75 ml,1.2 eq)，反应1-2 h,再加入1,2,3-trifluoro-4-methoxybenzene（4.64 g,1.0 eq）反应1-2 h,再加入干冰缓慢（干冰表面有水可以用四氢呋喃冲洗后加入，缓慢加入容易冲料。）回到室温反应12H.TLC检测反应完全（DCM/MEOH=10/1）,将反应液倒入1N的盐酸水溶液中，再用EA萃取，浓缩干燥得白色固体3.8 g.

实验步骤: 投料: 将原料溶解在THF50 ml，再加入碳酸钾（11.186 g,3.0 eq），搅拌30 min。再加入碘甲烷（5.75 g，1.5 eq）,升温60 ℃，反应4-5小时，TLC监测反应完全（PE/EA=10/1），过滤，ea冲洗，由白色滤液变成黄色滤液，干燥得黄色固体。

反应条件: temp:60.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 1,2,3-trifluoro-4-methoxybenzene (1.6 g, 10 mmol) in acetic acid (20 mL) was added nitric acid (5 mL) and the mixture was heated at 60° C. for 3 hours. After cooling to ambient temperature, water (100 mL) was added and the mixture was extracted with ethyl acetate (3×100 mL). The organic layers were concentrated to give the crude title compound, which was used in the next step without further purification. After cooling to ambient temperature the mixture was extracted with ethyl acetate (3×100 mL) The organic layers were concentrated

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 2,3,4-trifluoroanisole (Matrix) in an analogous manner as described in Example 169.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The compound was prepared from 4-amino-2-ethylsulfanyl-pyrimidine-5-carboxylic acid methoxy-methyl-amide, Example 1, and 2,3,4-trifluoroanisole (Matrix) in an analogous manner as described in Example 169.