tert-butyl N-[(2S)-1-oxo-1-piperazin-1-ylpropan-2-yl]carbamate

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 1.15 g of the N-hydroxysuccinimide ester of N-(tert-butoxycarbonyl)-L-alanine are dissolved in 100 ml of DMF and the solution is added dropwise over 6 hours to a mixture of 3.4 g (10 equivalents) of piperazine in 200 ml of DMF. The mixture is concentrated and the residue is taken up in water and extracted three times with 200 ml of dichloromethane each time. The organic phase is dried and the solvent is removed under reduced pressure. The target compound is obtained in a yield of 88%. [TLC: acetonitrile/water/glacial acetic acid 5:1:0.2 Rf =0.42]. The mixture is concentrated extracted three times with 200 ml of dichloromethane each time The organic phase is dried the solvent is removed under reduced pressure The target compound is obtained in a yield of 88%