(S)-1-(苄基氨基)-3-(苄氧基)丙-2-醇

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Benzyl-(S)-(+)-glycidyl ether (3.28 g) was dissolved in benzylamine (15 ml) and the mixture was stirred at room temperature for 4 days. Excess benzylamine was removed by evaporation in vacuo and the resulted residue was purified with a silica gel column chromatography (eluting solvent: chloroform to chloroform/methanol=9/1) to give (2S)-1-(benzylamino)-3-(benzyloxy)propane-2-ol (4.50 g) as a colorless oil. Excess benzylamine was removed by evaporation in vacuo the resulted residue was purified with a silica gel column chromatography (eluting solvent: chloroform to chloroform/methanol=9/1)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Benzyl-(S)-(+)-glycidyl ether (3.28 g) was dissolved in benzylamine (15 ml) and the mixture was stirred at room temperature for 4 days. Excess benzylamine was removed by evaporation in vacuo and the resulted residue was purified with a silica gel column chromatography (eluting solvent: chloroform to chloroform/methanol=9/1) to give (2S)-1-(benzylamino)-3-(benzyloxy)propane-2-ol (4.50 g) as a colorless oil. Excess benzylamine was removed by evaporation in vacuo the resulted residue was purified with a silica gel column chromatography (eluting solvent: chloroform to chloroform/methanol=9/1)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Benzyl-(S)-(+)-glycidyl ether (3.28 g) was dissolved in benzylamine (15 ml) and the mixture was stirred at room temperature for 4 days. Excess benzylamine was removed by evaporation in vacuo and the resulted residue was purified with a silica gel column chromatography (eluting solvent: chloroform to chloroform/methanol=9/1) to give (2S)-1-(benzylamino)-3-(benzyloxy)propane-2-ol (4.50 g) as a colorless oil. Excess benzylamine was removed by evaporation in vacuo the resulted residue was purified with a silica gel column chromatography (eluting solvent: chloroform to chloroform/methanol=9/1)