3,3-二甲基-2-戊酮

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 50 g of tert-amyl methyl ketone were dissolved in 50 ml of tetrahydrofuran and the solution was added dropwise at 0° C. to 330 ml of a 1.5 molar acetylene Grignard solution in tetrahydrofuran. After 30 min, the mixture was hydrolyzed with 2N hydrochloric acid, the organic phase was separated, the solvent was removed and the residue was then fractionally distilled. 52 g (85%) of 3,4,4-trimethylhex-1-yn-3-ol were obtained (b.p.: 110° C./175 mbar). the organic phase was separated the solvent was removed the residue was then fractionally distilled