4-溴苯基磷酸二乙酯

反应条件: temp:80.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 1,4-Dibromobenzene (2.36 g), diethyl phosphite (1.52 g) and triethylamine (1.53 ml) were dissolved in toluene, tetrakis(triphenylphosphine)palladium(0) (578 mg) was added, and the mixture was stirred at 80° C. for 2 hr. The reaction mixture was cooled to room temperature, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and brine, dried over sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1) to give the title compound (1.16 g). The reaction mixture was cooled to room temperature the mixture was extracted with ethyl acetate The organic layer was washed successively with water and brine dried over sodium sulfate concentrated under reduced pressure The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=1:1)