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CC(C)(C)OC(=O)NN1CCCC1中间体产品
tert-butyl N-pyrrolidin-1-ylcarbamate
结构、标识符和计算性质已按 CAS 与数据库记录完成匹配。
| 中文名称 | tert-butyl N-pyrrolidin-1-ylcarbamate |
|---|---|
| English name | tert-butyl N-pyrrolidin-1-ylcarbamate |
| IUPAC 名称 | — |
| CAS号 | 208245-82-3 |
| 数据库编号 | 21959621 |
| 分子式 | — |
| 分子量 | — |
产品信息
tert-butyl N-pyrrolidin-1-ylcarbamate（CAS 208245-82-3）的产品身份、结构标识及相关反应资料，供化学中间体检索、研发和采购评估使用。
可能的应用方向
仅供专业研发与工业用途
数据库编号 21959621
安全提示
仅供专业研发与工业用途。操作前请依据供应商提供的安全数据表完成风险评估。
合成路线数据
8 条反应 · 8 篇文献
反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 4′-{3-[(3R)-3-Aminopyrrolidinyl]propoxy}[1,1′-biphenyl]-4-carbonitrile and tert-butyl pyrrolidinylcarbamate were processed as described in Examples 9A-9C to provide the title compound.
来源 ID: ord-d3a18150282249a1b728cfb5a9c73d15反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 4′-{3-[(3R)-3-Aminopyrrolidinyl]propoxy}[1,1′-biphenyl]-4-carbonitrile and tert-butyl pyrrolidinylcarbamate were processed as described in Examples 9A-9C to provide the title compound.
来源 ID: ord-d3a18150282249a1b728cfb5a9c73d15反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A mixture of (3R)-(+)-(tert-butoxycarbonylaminopyrrolidine (1.0 g), p-fluorobenzonitrile (650 mg), cesium carbonate (1.75 g) and 5 ml of DMF was stirred at 50° C. for 12 h. Ethyl acetate and water were then added to the reaction solution, and the organic phase was washed twice with water, dried over sodium sulfate and filtered, and the solvent was removed in vacuo. The residue was purified by preparative HPLC. The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way; MS (ESI): 288.20 (M+H+). the organic phase was washed twice with water dried over sodium sulfate filtered the solvent was removed in vacuo The residue was purified by preparative HPLC The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way
来源 ID: ord-24ca460457ba4194abbf8b76cadf8e68反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A mixture of (3R)-(+)-(tert-butoxycarbonylaminopyrrolidine (1.0 g), p-fluorobenzonitrile (650 mg), cesium carbonate (1.75 g) and 5 ml of DMF was stirred at 50° C. for 12 h. Ethyl acetate and water were then added to the reaction solution, and the organic phase was washed twice with water, dried over sodium sulfate and filtered, and the solvent was removed in vacuo. The residue was purified by preparative HPLC. The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way; MS (ESI): 288.20 (M+H+). the organic phase was washed twice with water dried over sodium sulfate filtered the solvent was removed in vacuo The residue was purified by preparative HPLC The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way
来源 ID: ord-24ca460457ba4194abbf8b76cadf8e68反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A mixture of (3R)-(+)-(tert-butoxycarbonylaminopyrrolidine (1.0 g), p-fluorobenzonitrile (650 mg), cesium carbonate (1.75 g) and 5 ml of DMF was stirred at 50° C. for 12 h. Ethyl acetate and water were then added to the reaction solution, and the organic phase was washed twice with water, dried over sodium sulfate and filtered, and the solvent was removed in vacuo. The residue was purified by preparative HPLC. The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way; MS (ESI): 288.20 (M+H+). the organic phase was washed twice with water dried over sodium sulfate filtered the solvent was removed in vacuo The residue was purified by preparative HPLC The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way
来源 ID: ord-24ca460457ba4194abbf8b76cadf8e68反应条件: temp:50.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: A mixture of (3R)-(+)-(tert-butoxycarbonylaminopyrrolidine (1.0 g), p-fluorobenzonitrile (650 mg), cesium carbonate (1.75 g) and 5 ml of DMF was stirred at 50° C. for 12 h. Ethyl acetate and water were then added to the reaction solution, and the organic phase was washed twice with water, dried over sodium sulfate and filtered, and the solvent was removed in vacuo. The residue was purified by preparative HPLC. The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way; MS (ESI): 288.20 (M+H+). the organic phase was washed twice with water dried over sodium sulfate filtered the solvent was removed in vacuo The residue was purified by preparative HPLC The product with the molecular weight of 287.36 (C16H21N3O2) was obtained in this way
来源 ID: ord-e154934c1987442daa518fd3d6571095反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 4′-{3-[(3R)-3-Aminopyrrolidinyl]propoxy}[1,1′-biphenyl]-4-carbonitrile and tert-butyl pyrrolidinylcarbamate were processed as described in Examples 9A-9C to provide the title compound.
来源 ID: ord-dc8dd3a7d4fc4d9ca1cd93ffa3991a0b反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 4′-{3-[(3R)-3-Aminopyrrolidinyl]propoxy}[1,1′-biphenyl]-4-carbonitrile and tert-butyl pyrrolidinylcarbamate were processed as described in Examples 9A-9C to provide the title compound.
来源 ID: ord-d3a18150282249a1b728cfb5a9c73d15PubChem References
以下资料来自该化合物的公开数据库参考记录。
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