甲基 4-苯氧基丁酸甲酯

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 25.6 g of anhydrous aluminum trichloride are suspended in 64 ml of 1,2-dichloroethane, and 28.6 g of 4-methoxybenzoyl chloride are added. Then, while stirring vigorously, 31 g of methyl 4-phenoxybutyrate are slowly added. The reaction mixture is subsequently stirred at 50° C. for 4 hours, allowed to cool and poured into ice-water. The oily organic layer and the aqueous phase are separated, the organic phase is washed with water, and a little methanol is added to induce crystallization. The product which has separated out is filtered off with suction and recrystallized from ethyl acetate. The reaction mixture is subsequently stirred at 50° C. for 4 hours to cool The oily organic layer and the aqueous phase are separated the organic phase is washed with water a little methanol is added crystallization The product which has separated out is filtered off with suction recrystallized from ethyl acetate

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 25.6 g of anhydrous aluminum trichloride are suspended in 64 ml of 1,2-dichloroethane, and 28.6 g of 4-methoxybenzoyl chloride are added. Then, while stirring vigorously, 31 g of methyl 4-phenoxybutyrate are slowly added. The reaction mixture is subsequently stirred at 50° C. for 4 hours, allowed to cool and poured into ice-water. The oily organic layer and the aqueous phase are separated, the organic phase is washed with water, and a little methanol is added to induce crystallization. The product which has separated out is filtered off with suction and recrystallized from ethyl acetate. The reaction mixture is subsequently stirred at 50° C. for 4 hours to cool The oily organic layer and the aqueous phase are separated the organic phase is washed with water a little methanol is added crystallization The product which has separated out is filtered off with suction recrystallized from ethyl acetate

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Methyl 4-phenoxybutyrate was reacted with acetyl chloride in a similar manner to that described above for 3-[4-(chloroacetyl)phenyl]propionic acid, except that the crude product was triturated with petrol to give methyl 4-[4-(chloroacetyl)phenoxy]butyrate as a crystalline solid which was pure by TLC analysis (on silica plates; eluant: 50% ether/50% petrol). was triturated with petrol

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 25.6 g of anhydrous aluminum trichloride are suspended in 64 ml of 1,2-dichloroethane, and 28.6 g of 4-methoxybenzoyl chloride are added. Then, while stirring vigorously, 31 g of methyl 4-phenoxybutyrate are slowly added. The reaction mixture is subsequently stirred at 50° C. for 4 hours, allowed to cool and poured into ice-water. The oily organic layer and the aqueous phase are separated, the organic phase is washed with water, and a little methanol is added to induce crystallization. The product which has separated out is filtered off with suction and recrystallized from ethyl acetate. The reaction mixture is subsequently stirred at 50° C. for 4 hours to cool The oily organic layer and the aqueous phase are separated the organic phase is washed with water a little methanol is added crystallization The product which has separated out is filtered off with suction recrystallized from ethyl acetate