2-苯基戊醛

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a mixture of 5-[phenyl-pentanal (1.62 g, 10 mmol, 1.0 equiv) and methanol (50 ml) was added N-tert-butylhydroxylamine (0.93 g, 10.43 mmol, 1.25 equiv) followed by 10 drops of conc. HCl. The mixture was stirred at rt for 18 h. The mixture was concentrated under vacuum to yield a light colored oil. The residue oil was purified by column chromatography (hexane:EtOAc 1:1) followed by EtOAc to give the title compound as a lightly colored oil: Yield: 39%: 1H NMR (CDCl3) δ 7.20 (m, 5H), 6.94 (d, 1H), 2.50 (m, 4H), 1.60 (m, 4H), 1.46 (s, 9H). The mixture was concentrated under vacuum to yield a light colored oil The residue oil was purified by column chromatography (hexane:EtOAc 1:1)