三氟甲烷磺酸-3-甲氧基-2-(三甲基硅基)苯酯

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-methoxy-2-(trimethylsilyl)phenyl trifluoromethanesulfonate (25 mg, 0.076 mmol), Cesium Fluoride (63 mg, 0.419 mmol), Triethtyl phosphite (50 mg, 0.304 mmol), Acetonitrile (1 ml): Reaction Time: 24 h; Rf: 0.3 (2:3 EtOAc:Pet Ether); Thick oil; 13.7 mg, 74%; 1H NMR (200 MHz, CDCl3, TMS) δ 7.45-7.28 (m, 3H), 7.15-7.01 (m, 1H), 4.25-3.96 (m, 4H), 3.85 (s, 3H), 1.33 (t, J=7.1 Hz, 6H); 13C NMR (100 MHz, CDCl3, TMS) δ 159.4 (d, J=18.5 Hz), 129.7 (d, J=17.7 Hz), 129.6 (d, J=187.3 Hz), 124.0 (d, J=9.3 Hz), 118.8 (d, J=3.1 Hz), 116.4 (d, J=11.6 Hz), 62.2 (d, J=5.4 Hz), 55.41, 16.3 (d, J=6.2 Hz); 31P NMR (162 MHz, CDCl3) δ 18.7; Mass (M+Na)+ 267; Known Compound, Lit. G. Yang, C. Shen, L. Zhang, W. Zhang. Tetrahedron Lett. 2011, 52, 5032. 24 h