<SC>L</SC>-高丝氨酸内酯 盐酸盐

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and (35)-3-aminodihydro-2(3H)-furanone (CAN 2185-02-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 317.1500 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and (35)-3-aminodihydro-2(3H)-furanone (CAN 2185-02-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 317.1500 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and (35)-3-aminodihydro-2(3H)-furanone (CAN 2185-02-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 317.1500 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and (35)-3-aminodihydro-2(3H)-furanone (CAN 2185-02-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 317.1500 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: (S)-3-aminodihydrofuran-2(3H)-one hudrochloride (10.30 g, 74.87 mmol) in 58 mL of 30% w/w HBr in HOAc was stirred at 65° C. for 30 hrs. The solvent was removed under reduced pressure and the resulted solid was suspended in MTBE (200 mL) and stirred for 30 min. The solid was collected by filtration and washed with MTBE (200 mL) and dried to give (S)-2-amino-4-bromobutanoic acid hydrobromide as white solid (19.33 g, 98%). 1H NMR (400 MHz, d6-DMSO) δ 8.37 (s, 3H), 4.01 (m, 1H), 3.65 (m, 2H), 2.33 (m, 2H). The solvent was removed under reduced pressure The solid was collected by filtration washed with MTBE (200 mL) dried

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and (35)-3-aminodihydro-2(3H)-furanone (CAN 2185-02-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 317.1500 (M+H)+.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42a) and (35)-3-aminodihydro-2(3H)-furanone (CAN 2185-02-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 317.1500 (M+H)+.