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12 条反应 · 12 篇文献
反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-eecd7539dd504c818eb8b47fb343b431反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-fb6195fe24b5432282211959aec15edc反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-1c469086e8ae4b358677e9a16ddf1b2b反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-e5e1171ea38d4633865d78a5973af875反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: To a stirred mixture of phenylboronic acid (1.20 g, 9.85 mmol) and 4-bromo-2-fluorophenol (0.94 g, 4.92 mmol) in DCM (50.00 mL) was added cupric acetate (1.34 g, 7.39 mmol), powdered 4 A molecular sieves and TEA (3.43 mL, 24.6 mmol) at rt. The resulting mixture was then stirred at rt for 24 h at ambient atmosphere. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in hexane). at rt The solvent was then removed under reduced pressure the resulting residue was purified by flash chromatography (5% EtOAc in hexane)
来源 ID: ord-6956c1ae0431431aa5c96eac816ae40a反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: To a stirred mixture of phenylboronic acid (1.20 g, 9.85 mmol) and 4-bromo-2-fluorophenol (0.94 g, 4.92 mmol) in DCM (50.00 mL) was added cupric acetate (1.34 g, 7.39 mmol), powdered 4 A molecular sieves and TEA (3.43 mL, 24.6 mmol) at rt. The resulting mixture was then stirred at rt for 24 h at ambient atmosphere. The solvent was then removed under reduced pressure and the resulting residue was purified by flash chromatography (5% EtOAc in hexane). at rt The solvent was then removed under reduced pressure the resulting residue was purified by flash chromatography (5% EtOAc in hexane)
来源 ID: ord-6956c1ae0431431aa5c96eac816ae40a反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: The title compound was prepared in a 65% from 4-bromo-2-fluoro-1-phenoxybenzene in a similar manner to that described for the preparation 2-phenoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzonitrile: 1H NMR (DMSO-d6, 400 MHz) δ 7.49(dd, 2H), 7.41(m, 2H), 7.18 (t, 1H), 7.08(d, 1H), 7.05(d, 2H), 1.30(s, 12H); RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, I mmin) tr 14.63 min. tr 14.63 min.
来源 ID: ord-24c64e3d2f1545e7ad1538b1d7a47b59反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: The title compound was prepared in a 33% yield from 4-bromo-2-fluorophenol and phenyl boronic acid in a manner similar to that described for the preparation of 4-bromo-2-chloro-1-phenoxybenzene: 1H NMR (DMSO-d6, 400 MHz) δ 7.75(dd, 1H), 7.40(m, 3H), 7.15(m, 2H), 7.01(dd, 2H); MS MH+267.2; RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 ml/min) tr 13.57 min. tr 13.57 min.
来源 ID: ord-57ff8a9bd30246adb911baf6f2074ac0反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-eecd7539dd504c818eb8b47fb343b431反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-fb6195fe24b5432282211959aec15edc反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-1c469086e8ae4b358677e9a16ddf1b2b反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-e5e1171ea38d4633865d78a5973af875PubChem References
以下资料来自该化合物的公开数据库参考记录。