2-(2-氟苯氧基)-1-乙胺(HCL)

反应条件: temp:100.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Compound A (300 mg, 1.22 mmol), 2-(2-fluorophenoxy)ethylamine hydrochloride (700 mg) and sodium hydrogencarbonate (1.02 g) were added to DMSO (10 ml), and the mixture was stirred at 100° C. for 27 hr. After stirring, the reaction mixture was added to cold water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and concentrated, and the residue was washed by suspending in ethyl acetate. This was converted to hydrochloride to give the object compound of 2-(2-(2-fluorophenoxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile hydrochloride (126 mg). After stirring the mixture was extracted with ethyl acetate The organic layer was washed with saturated brine concentrated the residue was washed