暂无可渲染的结构数据
FC(C1=CC=CC=C1C(C)N)(F)F产品信息
1-(邻三氟甲基苯基)乙胺（CAS 273384-78-4）的产品身份、结构标识及相关反应资料，供化学中间体检索、研发和采购评估使用。
可能的应用方向
仅供专业研发与工业用途
数据库编号 2782450
安全提示
仅供专业研发与工业用途。操作前请依据供应商提供的安全数据表完成风险评估。
合成路线数据
12 条反应 · 12 篇文献
反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-c5677cf3287e4d37a109b1d9dccdefb5反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-4b3bf6f75ef34627bf30faadf092c1bc反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-3e697578ba174cbc989e02fcea4015bc反应条件: temp:0.00; pressure:0.00; stir:
来源 ID: ord-c5677cf3287e4d37a109b1d9dccdefb5反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-0e6c22c4780947d696294e3786e6dc6f反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-0e6c22c4780947d696294e3786e6dc6f反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-407cc49ac6b64d318e0955a94bd911d2反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-1fdcf0bbd2564ef0940884fac4edcba1反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: 5 Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with IN hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g) The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with IN hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-f68d87eb7f324c3ea19bc2f1e5eccb06反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-774a45b8eaa04f5bb093ceb700f6a576反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-14a1e8e04be849c9998f38d1254365c0反应条件: temp:25.01; pressure:0.00; stir:; See reaction.notes.procedure_details.
实验步骤: Sodium borohydride (1.17 g) is added slowly to a flask containing zirconium tetrachloride (1.8 g) in tetrahydrofuran (27 mL). A solution of 1-(2-trifluoromethyl-phenyl)-ethanone O-methyl-oxime (1.34 g) in tetrahydrofuran (7.7 mL) is added and the resulting solution is stirred at 25° C. for 12 hours. The reaction mixture is then cooled to 0° C. and water (16 mL) is slowly added. Excess ammonium hydroxide is added and the solution is extracted twice with ethyl acetate. The organic portion is washed twice with 1N hydrochloric acid. The aqueous (acid) layer is basified with sodium hydroxide and extracted twice with ethyl acetate. The organic layer is then washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. The solvent is removed under reduced pressure to provide the desired product as a yellow oil (0.20 g). The reaction mixture is then cooled to 0° C. the solution is extracted twice with ethyl acetate The organic portion is washed twice with 1N hydrochloric acid extracted twice with ethyl acetate The organic layer is then washed with saturated aqueous sodium chloride dried over anhydrous magnesium sulfate The solvent is removed under reduced pressure
来源 ID: ord-bf198f1bc95f4917a42738ced1ef6e3dPubChem References
以下资料来自该化合物的公开数据库参考记录。