7-氟吲哚满二酮

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Following the procedure as described in PREPARATION 1A, and making tnon-critical variations to replace 4-bromoindole with 7-fluoroisatin, and 1-bromopentane with 2-(bromomethyl)-5-(trifluoromethyl)furan, the title compound was obtained (34%): MS (ES+) m/z 336.2 (M+23).

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Methanol (25 mL) was vigorously stirred under nitrogen for 20 min and then 7-fluoroisatin (IIIa) (150 mg, 0.91 mmol) and 3-acetoxyindole (106 mg, 0.61 mmol) were added and stirring was Continued for 5 min. Anhydrous Na2CO3 (155 mg) was added and the stirring was continued for 3 h. The dark precipitate was filtered and washed with aqueous methanol (1:1, 20 mL) to give 7 (130 mg, 0.46 mmol, 77%) selectively in a Z form. 1H NMR (DMSO, 400 MHz, δ ppm, J in Hz) 11.37 (1H, s, N′—H), 11.12 (1H, s, N—H), 8.58 (1H, d, J=7.7 Hz, H-4), 7.64 (1H, d, J=7.5 Hz, H-4′), 7.57 (1H, t, J=7.5 Hz H-6′), 7.42 (1H, d, J=7.5 Hz, H-7′), 7.15 (1H, t, J=8.0 Hz, H-5), 7.02 (2H, m, H-5′, 6); CI-MS m/z 281 (M+H)+. Anal. (C16H9N2O2F) C, H, N. the stirring was continued for 3 h The dark precipitate was filtered washed with aqueous methanol (1:1, 20 mL)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Methanol (25 mL) was vigorously stirred under nitrogen for 20 min and then 7-fluoroisatin (IIIa) (150 mg, 0.91 mmol) and 3-acetoxyindole (106 mg, 0.61 mmol) were added and stirring was Continued for 5 min. Anhydrous Na2CO3 (155 mg) was added and the stirring was continued for 3 h. The dark precipitate was filtered and washed with aqueous methanol (1:1, 20 mL) to give 7 (130 mg, 0.46 mmol, 77%) selectively in a Z form. 1H NMR (DMSO, 400 MHz, δ ppm, J in Hz) 11.37 (1H, s, N′—H), 11.12 (1H, s, N—H), 8.58 (1H, d, J=7.7 Hz, H-4), 7.64 (1H, d, J=7.5 Hz, H-4′), 7.57 (1H, t, J=7.5 Hz H-6′), 7.42 (1H, d, J=7.5 Hz, H-7′), 7.15 (1H, t, J=8.0 Hz, H-5), 7.02 (2H, m, H-5′, 6); CI-MS m/z 281 (M+H)+. Anal. (C16H9N2O2F) C, H, N. the stirring was continued for 3 h The dark precipitate was filtered washed with aqueous methanol (1:1, 20 mL)

反应条件: temp:70.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 19.27 g of the product of Step B and 197 ml of 10N sodium hydroxide solution was heated to 70° C. with stirring and heating was ceased to add 36.5 ml of 30% hydrogen peroxide over 20 minutes during which the temperature rose to 80° C. and descended to 70° C. At the end of the addition, the mixture was heated to 80° C. and held there for 10 minutes and then was cooled during which a mass formed. The latter was added to 200 ml of water with stirring and the pH was adjusted to 1 by addition of concentrated hydrochloric acid at a temperature less than 20° C. The mixture was stirred for 90 minutes and was vacuum filtered. The product was empasted twice with iced water and dried under reduced pressure at 70° C. The product was crystallized from 100 ml of a 1-1 ethanol-water mixture and 3 ml of acetic acid. The mixture was iced for one hour and was vacuum filtered. The product was empasted with a 1-1 ethanol-water mixture and dried at 70° C. under reduced pressure to obtain 14.8 g of 2-amino-3-fluoro-benzoic acid melting at 188° C. heating rose to 80° C. descended to 70° C At the end of the addition the mixture was heated to 80° C. was cooled during which a mass formed with stirring The mixture was stirred for 90 minutes filtered dried under reduced pressure at 70° C The product was crystallized from 100 ml of a 1-1 ethanol-water mixture and 3 ml of acetic acid The mixture was iced for one hour filtered dried at 70° C. under reduced pressure