环庚烷甲酸乙酯

反应条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a stirred solution of ethyl cycloheptane carboxylate (14 g, 82.4 mmol, prepared by esterification of the acid, which was obtained from Aldrich, by refluxing in ethanol in the presence of an acid catalyst), in 600 mL anhydrous THF cooled to -78° C. was added 60 mL of 1.5M LDA (monotetrahydrofuran in hexane, Aldrich) via syringe. The resulting light yellow reaction solution was stirred at -78° C. for 45 min and the benzyl bromide (from step A above) was added (19 g dissolved in 75 mL of THF, 82.4 mmol). The reaction was stirred at -78° C. for 4 hours, then it was quenched by addition of sat'd. NH4Cl, water and ether. The layers were separated, and the organic layer was washed with 1M HCl, water, and brine. The organic layer was dried over MgSO4, filtered, and evaporated to yield a light amber oil (28 g) which was used without further purification. The reaction was stirred at -78° C. for 4 hours it was quenched by addition of sat'd The layers were separated the organic layer was washed with 1M HCl, water, and brine The organic layer was dried over MgSO4 filtered evaporated

反应条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a stirred solution of ethyl cycloheptane carboxylate (14 g, 82.4 mmol, prepared by esterification of the acid, which was obtained from Aldrich, by refluxing in ethanol in the presence of an acid catalyst), in 600 mL anhydrous THF cooled to -78° C. was added 60 mL of 1.5M LDA (monotetrahydrofuran in hexane, Aldrich) via syringe. The resulting light yellow reaction solution was stirred at -78° C. for 45 min and the benzyl bromide (from step A above) was added (19 g dissolved in 75 mL of THF, 82.4 mmol). The reaction was stirred at -78° C. for 4 hours, then it was quenched by addition of sat'd. NH4Cl, water and ether. The layers were separated, and the organic layer was washed with 1M HCl, water, and brine. The organic layer was dried over MgSO4, filtered, and evaporated to yield a light amber oil (28 g) which was used without further purification. The reaction was stirred at -78° C. for 4 hours it was quenched by addition of sat'd The layers were separated the organic layer was washed with 1M HCl, water, and brine The organic layer was dried over MgSO4 filtered evaporated

反应条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a stirred solution of ethyl cycloheptane carboxylate (14 g, 82.4 mmol, prepared by esterification of the acid, which was obtained from Aldrich, by refluxing in ethanol in the presence of an acid catalyst), in 600 mL anhydrous THF cooled to -78° C. was added 60 mL of 1.5M LDA (monotetrahydrofuran in hexane, Aldrich) via syringe. The resulting light yellow reaction solution was stirred at -78° C. for 45 min and the benzyl bromide (from step A above) was added (19 g dissolved in 75 mL of THF, 82.4 mmol). The reaction was stirred at -78° C. for 4 hours, then it was quenched by addition of sat'd. NH4Cl, water and ether. The layers were separated, and the organic layer was washed with 1M HCl, water, and brine. The organic layer was dried over MgSO4, filtered, and evaporated to yield a light amber oil (28 g) which was used without further purification. The reaction was stirred at -78° C. for 4 hours it was quenched by addition of sat'd The layers were separated the organic layer was washed with 1M HCl, water, and brine The organic layer was dried over MgSO4 filtered evaporated