2-(3-氧-2-哌嗪基)乙酸乙酯

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Prepared analogously to Example 1g from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and 3-(ethoxycarbo-nylmethyl)piperazin-2-one in DMF. Yield: 37%; Rf value: 0.49 (silica gel; dichloromethane/ethanol=10:1); C25H25Cl2N5O5 (546.41); mass spectrum: (M+H)+=546/548/550 (chlorine isotope).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Ethylenediamine (1.17 ml, 17.42 mmol) and diethyl maleate (3 g, 17.42 mmol) were stirred for 16 h at 55° C. in propanol (30 ml). The solvent was removed in vacuo and the residue was dried in vacuo. The product was used in the next stage without being purified further. The solvent was removed in vacuo the residue was dried in vacuo without being purified further