N-(3-溴苄基)乙酰胺

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (3.30 g), N-(3-bromobenzyl)acetamide (1.05 g) and tetrakis(triphenylphosphine)palladium(0) (0.18 g), the title compound (1.24 g) was obtained as a pale-yellow amorphous powder.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (3.30 g), N-(3-bromobenzyl)acetamide (1.05 g) and tetrakis(triphenylphosphine)palladium(0) (0.18 g), the title compound (1.24 g) was obtained as a pale-yellow amorphous powder.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 3-bromobenzylamine hydrochloride (5.20 g) in pyridine (30 ml) was added acetic anhydride (3.2 ml) at 0° C. and the mixture was stirred at room temperature for 24 h. Water and ethyl acetate were added to the reaction mixture for partitioning, and the organic layer was washed with 1N hydrochloric acid, aqueous sodium hydrogen carbonate and brine, dried (magnesium sulfate) and concentrated under reduced pressure. The residue was recrystallized from hexane-ethyl acetate to give the title compound (4.00 g) as colorless needle crystals. for partitioning the organic layer was washed with 1N hydrochloric acid, aqueous sodium hydrogen carbonate and brine dried (magnesium sulfate) concentrated under reduced pressure The residue was recrystallized from hexane-ethyl acetate

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (3.30 g), N-(3-bromobenzyl)acetamide (1.05 g) and tetrakis(triphenylphosphine)palladium(0) (0.18 g), the title compound (1.24 g) was obtained as a pale-yellow amorphous powder.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 3-bromobenzylamine hydrochloride (5.20 g) in pyridine (30 ml) was added acetic anhydride (3.2 ml) at 0° C. and the mixture was stirred at room temperature for 24 h. Water and ethyl acetate were added to the reaction mixture for partitioning, and the organic layer was washed with 1N hydrochloric acid, aqueous sodium hydrogen carbonate and brine, dried (magnesium sulfate) and concentrated under reduced pressure. The residue was recrystallized from hexane-ethyl acetate to give the title compound (4.00 g) as colorless needle crystals. for partitioning the organic layer was washed with 1N hydrochloric acid, aqueous sodium hydrogen carbonate and brine dried (magnesium sulfate) concentrated under reduced pressure The residue was recrystallized from hexane-ethyl acetate