苄胺氢溴酸盐

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±)-trans-2-benzylamino-6-propyl-5,5a, 6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline (Rf=0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl -5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±) -trans-2-benzylamino-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido [2,3-g]quinoline (Rf=0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl -5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±) -trans-2-benzylamino-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido [2,3-g]quinoline (Rf=0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±)-trans-2-benzylamino-6-propyl-5,5a, 6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline (Rf=0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±)-trans-2-benzylamino-6-propyl-5,5a, 6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline (Rf=0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)

反应条件: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 7.84 parts of 3,4-dihydro-8-phenylisocoumarin and 8 parts of benzylamine hydrobromide in 40 parts by volume of benzylamine is stirred at about 160° C. for about 4 hours. The reaction solution is then cooled and poured into 500 parts by volume of 5% hydrochloric acid. The oil which separates is extracted into methylene chloride and the extracts are washed with several portions of 5% hydrochloric acid, water, dried over anhydrous magnesium sulfate and the solvent removed to give, as a solid, N-benzyl-3-(2-hydroxyethyl)-2-biphenylcarboxamide. The solid is recrystallized from a mixture of chloroform and hexane to give white flocculant crystals melting at about 129°-130° C. This compound has the following formula ##STR13## The reaction solution is then cooled The oil which separates is extracted into methylene chloride the extracts are washed with several portions of 5% hydrochloric acid, water dried over anhydrous magnesium sulfate the solvent removed

反应条件: temp:160.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of 7.84 parts of 3,4-dihydro-8-phenylisocoumarin and 8 parts of benzylamine hydrobromide in 40 parts by volume of benzylamine is stirred at about 160° C. for about 4 hours. The reaction solution is then cooled and poured into 500 parts by volume of 5% hydrochloric acid. The oil which separates is extracted into methylene chloride and the extracts are washed with several portions of 5% hydrochloric acid, water, dried over anhydrous magnesium sulfate and the solvent removed to give, as a solid, N-benzyl-3-(2-hydroxyethyl)-2-biphenylcarboxamide. The solid is recrystallized from a mixture of chloroform and hexane to give white flocculant crystals melting at about 129°-130° C. This compound has the following formula ##STR13## The reaction solution is then cooled The oil which separates is extracted into methylene chloride the extracts are washed with several portions of 5% hydrochloric acid, water dried over anhydrous magnesium sulfate the solvent removed

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±)-trans-2-benzylamino-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline (Rf=0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 32.2 g of benzylamine, 14.8 g of 4-bromobutyronitrile and 30 ml of cyclohexane are stirred at room temperature for 12 hours. After the addition of diethyl ether the separated benzylamine hydrobromide is filtered off; the ether phase is washed with water, dried and concentrated by evaporation. The residue is distilled in vacuo to yield 11.5 g (66% of theory) of 4-benzylaminobutyronitrile (B.P. 114° to 120°/0.05 mm Hg). is filtered off the ether phase is washed with water dried concentrated by evaporation The residue is distilled in vacuo

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±)-trans-2-benzylamino-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline (Rf =0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl -5,5a,6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±) -trans-2-benzylamino-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido [2,3-g]quinoline (Rf=0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)

反应条件: temp:240.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of (±)-trans-2-chloro-6-propyl-5,5a,6,7,8,9,9a,10-octahydropyrido2,3-g]quinoline hydrochloride (2.27 g, 7.50 mmol) and benzylamine hydrobromide (15.0 g) was heated to 240° C. to form a brown, molten semi-solid. After 15 minutes, the molten semi-solid was poured into water, made basic with dilute NaOH solution, and extracted with methylene chloride. The extract was dried (Na2SO4) and concentrated to give a brown oil. Purification by flash chromatography (6% methanol in methylene chloride, NH4OH) provided (±)-trans-2-benzylamino-6-propyl-5,5a, 6,7,8,9,9a,10-octahydropyrido[2,3-g]quinoline (Rf=0.35, 561 mg, 22% yield) as a brown oil. to form a brown, molten semi-solid extracted with methylene chloride The extract was dried (Na2SO4) concentrated to give a brown oil Purification by flash chromatography (6% methanol in methylene chloride, NH4OH)