(2R)-2-乙基环氧乙烷

反应条件: temp:-78.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: The 1-bromo-2-ethylbenzene (2.0 g) was dissolved in dry THF and the mixture was cooled to −78° C. 1.6 M n-BuLi (20.26 ml) was slowly added to the reaction mixture and then the mixture was stirred at −78° C. After 1 h (R)-(+)-1,2-epoxybutane (1.1 g) was added in 10 ml of THF. The reaction mixture was allowed to warm to ambient temperature and then stirred over night. The reaction was quenched with ice-water and product extracted in heptanes, and finally purified by using the separation method E yielding the title compound (1.1 g). to warm to ambient temperature stirred over night The reaction was quenched with ice-water and product extracted in heptanes finally purified the separation method E

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 2-Iodobenzotrifluoride (3 g) was dissolved in THF (18 ml) and was cooled to −78° C. n-BuLi (2.5 M in hexanes, 13.23 ml) was added dropwise to the reaction mixture. After 1 h, (R)-(+)-1,2-epoxybutane (1.4 ml) in THF (18 ml) was added. The reaction temperature was slowly increased to rt. The mixture was poured into ice-water (100 ml), and the product was extracted with heptane. The organic phase was washed with brine and water, dried (Na2SO4) ja evaporated under vacuum. The title compound was obtained by separation method E. (Yield 1.05 g). was added dropwise to the reaction mixture the product was extracted with heptane The organic phase was washed with brine and water dried (Na2SO4) ja evaporated under vacuum