甲基 3-(3-羟基苯基)丙-2-烯酸乙酯

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-(3-Hydroxy-phenyl)-acrylic acid methyl ester (85 mg, 0.48 mmol) was dissolved in dry DMF (1.5 ml) and NaH (14 mg, 0.60 mmol) was added as a suspension in heptane (0.5 ml). The mixture was stirred at room temperature for 10 min. 4-Chloromethyl-2-phenyl-thiazole (100 mg, 0.48 mmol) was added portion-wise and the solution left stirring for 4 h. The reaction mixture was quenched with H2O (2 ml) and extracted with EtOAc (3×1 ml). The combined organic layers were washed with H2O (3×1 ml), dried (MgSO4), filtered and the solvent removed in vacuo to give a mixture of acid and ester, which was used without further purification. the solution left stirring for 4 h The reaction mixture was quenched with H2O (2 ml) extracted with EtOAc (3×1 ml) The combined organic layers were washed with H2O (3×1 ml) dried (MgSO4) filtered the solvent removed in vacuo to give was used without further purification

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-(3-Hydroxy-phenyl)-acrylic acid (2 g, 12.2 mmol) was esterified with MeOH using Method B to give the title compound.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-(3-Hydroxy-phenyl)-acrylic acid methyl ester (85 mg, 0.48 mmol) was dissolved in dry DMF (1.5 ml) and NaH (14 mg, 0.60 mmol) was added as a suspension in heptane (0.5 ml). The mixture was stirred at room temperature for 10 min. 4-Chloromethyl-2-phenyl-thiazole (100 mg, 0.48 mmol) was added portion-wise and the solution left stirring for 4 h. The reaction mixture was quenched with H2O (2 ml) and extracted with EtOAc (3×1 ml). The combined organic layers were washed with H2O (3×1 ml), dried (MgSO4), filtered and the solvent removed in vacuo to give a mixture of acid and ester, which was used without further purification. the solution left stirring for 4 h The reaction mixture was quenched with H2O (2 ml) extracted with EtOAc (3×1 ml) The combined organic layers were washed with H2O (3×1 ml) dried (MgSO4) filtered the solvent removed in vacuo to give was used without further purification

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-(3-Hydroxy-phenyl)-acrylic acid (2 g, 12.2 mmol) was esterified with MeOH using Method B to give the title compound.

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-(3-Hydroxy-phenyl)-acrylic acid methyl ester (85 mg, 0.48 mmol) was dissolved in dry DMF (1.5 ml) and NaH (14 mg, 0.60 mmol) was added as a suspension in heptane (0.5 ml). The mixture was stirred at room temperature for 10 min. 4-Chloromethyl-2-phenyl-thiazole (100 mg, 0.48 mmol) was added portion-wise and the solution left stirring for 4 h. The reaction mixture was quenched with H2O (2 ml) and extracted with EtOAc (3×1 ml). The combined organic layers were washed with H2O (3×1 ml), dried (MgSO4), filtered and the solvent removed in vacuo to give a mixture of acid and ester, which was used without further purification. the solution left stirring for 4 h The reaction mixture was quenched with H2O (2 ml) extracted with EtOAc (3×1 ml) The combined organic layers were washed with H2O (3×1 ml) dried (MgSO4) filtered the solvent removed in vacuo to give was used without further purification

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 3-(3-Hydroxy-phenyl)-acrylic acid (2 g, 12.2 mmol) was esterified with MeOH using Method B to give the title compound.