4-(3-氨基苯基)丁-2-one

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of (E)-4-(3-nitrophenyl)but-3-en-2-one (15 g, 78 mmol) in EtOAc (150 mL) was added Pd/C (1.7 g), H2 was bubbled in, the reaction mixture was stirred at 40 psi H2 for 4 hrs. The mixture was filtrated, and the filtrate was concentrated to give 4-(3-aminophenyl)butan-2-one (12 g, 94% yield). 1H NMR: (400 MHz, CDCl3) δ 7.08 (t, 1H), 6.63 (s, 1H), 6.54 (d, 1H), 6.42 (d, 1H), 2.76 (t, 2H), 2.71 (t, 2H), 2.1 (s, 3H). was bubbled in, the reaction mixture The mixture was filtrated the filtrate was concentrated