2-氯-4-氟乙酰苯胺

反应条件: temp:0.00; pressure:0.00; stir:

反应条件: temp:6.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 2′-chloro-4′-fluoroacetanilide (85.5 g, 456 mmol) in concentrated sulfuric acid is cooled to 0° C., treated slowly with 70% nitric acid (32 mL, 502 mmol) while maintaining the temperature from 5-8° C., stirred at room temperature overnight and poured into water. The resultant aqueous mixture is filtered to obtain a solid which is recrystallized from ethanol to give the title product as pale, yellow plates (27.0 g, mp 158-160° C.). The resultant aqueous mixture is filtered to obtain a solid which is recrystallized from ethanol

反应条件: temp:6.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 2′-chloro-4′-fluoroacetanilide (85.5 g, 456 mmol) in concentrated sulfuric acid is cooled to 0° C., treated slowly with 70% nitric acid (32 mL, 502 mmol) while maintaining the temperature from 5-8° C., stirred at room temperature overnight and poured into water. The resultant aqueous mixture is filtered to obtain a solid which is recrystallized from ethanol to give the title product as pale, yellow plates (27.0 g, mp 158-160° C.). The resultant aqueous mixture is filtered to obtain a solid which is recrystallized from ethanol

反应条件: temp:0.01; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A mixture of N-(2-chloro-4-fluorophenyl)acetamide (25.0 g, 133 mmol), concentrated hydrochloric acid (25 ml) and ethanol(50 ml) was heated at reflux for 3 h. The mixture was cooled to 0° C. and left for crystallisation. The precipitate was collected and dried in vacuo to give 20.0 g of 2-chloro-4-fluorophenylammonium chloride. was heated at reflux for 3 h left for crystallisation The precipitate was collected dried in vacuo

反应条件: temp:6.51; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: A solution of 2′-chloro-4′-fluoroacetanilide (85.5 g, 456 mmol) in concentrated sulfuric acid is cooled to 0° C., treated slowly with 70% nitric acid (32 mL, 502 mmol) while maintaining the temperature from 5-8° C., stirred at room temperature overnight and poured into water. The resultant aqueous mixture is filtered to obtain a solid which is recrystallized from ethanol to give the title product as pale, yellow plates (27.0 g, mp 158-160° C.). The resultant aqueous mixture is filtered to obtain a solid which is recrystallized from ethanol