(1R)-3-(二甲氨基)-1-苯基丙-1-醇

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Chiral hydrogenation of 3-(dimethylamino)propiophenone was carried out (see formula (13) below). That is, a reaction was carried out in accordance with the procedures of Example 4 using the (S,SS)-ruthenium hydride complex synthesized in Example 2 and using 3-(dimethylamino)propiophenone(886 mg; 5.0 mmol) as the substrate and 2-propanol (5 mL) as the solvent. However, the hydrogen pressure was set to 8 atmosphere, the reaction temperature was set to 250° C., and the reaction time was set to 12 hours. As a result, (R)-1-phenyl-3-(dimethylamino)propane-1-ol was obtained at a conversion rate of 100%, isolation yield of 89% (796 mg; 4.45 mmol), and enantiomeric excess of 97%. HPLC (column: CHIRALCEL OD; size: 4.6 mm×250 mm; made by Daicel Chemical Industries Ltd.; solvent: 9:1 hexane/2-propanol; temperature: 30° C.; UV wavelength: 254 nm; flow rate: 0.5 ml/minute; tR of (R)-1-phenyl-3-(dimethylamino)propane-1-ol: 14.4 minutes (98.4%); tR of S alcohol: 20.4 minutes (1.6%)); [α]26D+31.8° (c: 1.67; CH3OH); absolute structure: R; literature value: [α]D+27.6° (c:1.61; CH3OH),(R). was set to 250° C.