3-哌嗪基丙酸甲酯

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: 1.13 g of 3-[2-(1-(5-oxo-1,2,4-oxadiazolin-3-yl)-4-piperazinyl)ethyl]-5-[4-(2-carboxyethyl)piperazino]methyloxazolidin-2-one [obtainable according to Ex. 1 by reaction of methyl 3-piperazinopropanoate with 3-[2-(1-(5-oxo-1,2,4-oxadiazolin-3-yl)-4-piperazinyl)ethyl]-5-methanesulfonylmethyloxazolidin-2-one and subsequent hydrolysis of the product] are dissolved in 50 ml of methanol and hydrogenated on Raney Nickel. The reaction mixture is then filtered and the filtrate is concentrated in vacuo. The product obtained is treated with 20 ml of ethyl acetate in the presence of heat and filtered off with suction after cooling. 3-[2-(1-Amidino-4-piperazinyl)ethyl]-5-[4-(2-carboxyethyl)piperazino]methyloxazolidin-2-one is obtained. The reaction mixture is then filtered the filtrate is concentrated in vacuo The product obtained of heat filtered off with suction after cooling