二环己基甲醇

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Dicyclohexylmethanol (8-1) (4.91 g, 25 mmol) and ethyl 4-hydroxybenzoate (8-2) (4.15 g, 25 mmol) were reacted, as in Example 6, Step B, to obtain a colorless oil 8-3 after chromatography. 1H NMR (CDCl3): δ 0.98-1.3 (11H, m), 1.36 (3H, t), 1.58-1.86 (11H, m), 4.02 (1H, t), 4.33 (2H, q), 6.92 (2H, d), 7.94 (2H, d).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Dicyclohexylmethanol (8-1) (4.91 g, 25 mmol) and ethyl 4-hydroxybenzoate (8-2) (4.15 g, 25 mmol) were reacted, as in Example 6, Step B, to obtain a colorless oil 8-3 after chromatography. 1H NMR (CDCl3): δ 0.98-1.3 (11H, m), 1.36 (3H, t), 1.58-1.86 (11H, m), 4.02 (1H, t), 4.33 (2H, q), 6.92 (2H, d), 7.94 (2H, d).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Dicyclohexylmethanol (8-1) (4.91 g, 25 mmol) and ethyl 4-hydroxybenzoate (8-2) (4.15 g, 25 mmol) were reacted, as in Example 6, Step B, to obtain a colorless oil 8-3 after chromatography. 1H NMR (CDCl3): δ 0.98-1.3 (11H, m), 1.36 (3H, t), 1.58-1.86 (11H, m), 4.02 (1H, t), 4.33 (2H, q), 6.92 (2H, d), 7.94 (2H, d).

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: To a solution of 3-hydroxybenzoic acid (1.61 g, 8.2 mmol), dicyclohexylmethanol (1.61 g, 8.2 mmol), triphenylphosphine (2.05 g, 7.82 mmol) and dioxane (35 ml) was added diethyl azodicarboxylate (1.41 ml, 8.94 mmol), and the resultant mixture was refluxed for 3 days. The reaction mixture was allowed to warm up to room temperature, poured into chilled water and extracted with diethyl ether. The organic layer was concentrated, and the residue was dissolved in a mixture of methanol (20 ml), tetrahydrofuran (6.5 ml) and water (2.0 ml), mixed with potassium hydroxide (1.16 g) and stirred for 2 hours. The mixture was poured into chilled water, acidified, and extracted with ethyl acetate. The organic layer was concentrated, and the resultant residue was recrystallized from hexane to give the titled compound (0.43 g, yield 18%). poured extracted with diethyl ether The organic layer was concentrated the residue was dissolved in a mixture of methanol (20 ml), tetrahydrofuran (6.5 ml) and water (2.0 ml) mixed with potassium hydroxide (1.16 g) The mixture was poured into chilled water extracted with ethyl acetate The organic layer was concentrated the resultant residue was recrystallized from hexane

反应条件: temp:0.00; pressure:0.00; stir:; See reaction.notes.procedure_details.

实验步骤: Dicyclohexylmethanol (8-1) (4.91 g, 25 mmol) and ethyl 4-hydroxybenzoate (8-2) (4.15 g, 25 mmol) were reacted, as in Example 6, Step B, to obtain a colorless oil 8-3 after chromatography. 1H NMR (CDCl3): δ 0.98-1.3 (11H, m), 1.36 (3H, t), 1.58-1.86 (11H, m), 4.02 (1H, t), 4.33 (2H, q), 6.92 (2H, d), 7.94 (2H, d).